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引用次数: 0
摘要
邻氨基- n -(1,1-二甲基丙-2-炔基)-苯酰胺3与氯甲酸乙酯羰基化得到2-碳氧基氨基- n -(1,1-二甲基丙-2-炔基)-苯酰胺6。在基本条件下对6进行环化，得到的不是喹唑啉8，而是恶唑7。当3也在三乙基甲甲酸乙酯-乙酸酐混合物中回流时，形成2-乙酰氨基- n-(1,1-二甲基丙-2-炔基)-苯甲酰胺4作为主要化合物，3-(1,1-二甲基丙-2-炔基)-喹唑啉-4-(3H)- 1- 5的量可忽略。
REACTIONS OF O-AMINO-N-(1,1-DIMETHYLPROP-2-YNYL)-BENZAMIDE
Carbonylation of o-amino-N-(1,1-dimethylprop-2-ynyl)-benzamide 3 with ethyl chloroformate gave 2-carbethoxyamino-N-(1,1-dimethylprop- 2-ynyl)-benzamide 6. Attempted cyclization of 6 under basic conditions did not give the quinazoline 8 but an oxazole 7. When 3 was also refluxed in triethylorthoformate-acetic anhydride mixture, 2-acetylamino-N-(1,1-dimethylprop- 2-ynyl)-benza-mide 4 was formed as the major compound with negligible amount of 3-(1,1- dimethylprop-2-ynyl)-quinazolin-4-(3H)-one 5.
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