基于沙门氏菌试验和微核试验的甲基菲和苯基菲致突变活性评价

K. Rudnicka, S. Tejs, Kinga A. Budzikur, Danuta Miel ̋yƒska, Švach, E. Jakimiuk, Anna Chachaj, M. Góra, Kamila ̊elazna, Michał K. Łuczyƒski
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引用次数: 2

摘要

所研究的化合物在存在(+S9)和不存在(-S9)外源代谢激活的情况下的诱变活性。这些化合物还在体外染色体畸变试验中进行了测试,其中V-79细胞暴露于菲衍生物中,研究了存在和不存在代谢激活的情况。苯基菲无致突变作用。在Ames试验中,这些化合物偶尔会引起复归物数量的显著减少。代谢激活(+S9)后,1-甲基菲的致突变作用最大。在微核试验中,4-甲基菲在代谢激活系统存在的情况下也表现出最大的诱变效应。所获得的结果与先前报道的甲基菲的结果相当。基于沙门氏菌试验和微核试验的甲基苯基菲致突变活性评价
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of mutagenic activity of methyl- and phenylphenanthrenes based on Salmonella test and micronucleus test
mutagenic activity of studied compounds both in the presence (+S9) and in the absence (-S9) of an exogenous source of metabolic activation. The compounds were also tested in an in vitro chromosome aberration assay in which V-79 cells were exposed to the phenanthrene derivatives investigated both in the presence and in the absence of metabolic activation. The phenylphenanthrenes showed no mutagenic effect. These compounds occasionally induced significant decrease in the number of revertants in the Ames test. The greatest mutagenic effects were observed for 1-methylphenanthrene after metabolic activation (+S9). In the micronucleus test the greatest mutagenic effect was observed for 4-methylphenanthrene also in the presence of metabolic activation system. The results obtained are comparable to those reported earlier for the methylphenanthrenes. Assessment of mutagenic activity of methyland phenylphenanthrenes based on Salmonella test and micronucleus test
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