泛素特异性蛋白酶对肿瘤放射敏感性的影响

国际肿瘤学杂志 Pub Date : 2019-07-08 DOI:10.3760/CMA.J.ISSN.1673-422X.2019.07.006

Qifen Zhou, Chunlin Wu

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引用次数: 0

摘要

泛素特异性蛋白酶是去泛素化酶家族的一员，具有逆转蛋白质泛素化和稳定蛋白质的作用。它通过调节DNA损伤、细胞周期、核因子-κB信号通路、Nrf2-Keap1信号通路和癌基因c-myc影响肿瘤的放射敏感性。有望成为肿瘤放疗增敏的新靶点。关键词:肿瘤;辐射宽容;泛素特异性蛋白酶

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Effect of ubiquitin-specific protease on radiosensitivity of tumor

Ubiquitin-specific protease is a member of the deubiquitinating enzyme family, which can reverse the ubiquitination of proteins and stabilize proteins. It affects radiosensitivity of tumor by regulating DNA damage, cell cycle, nuclear factor-κB signaling pathway, Nrf2-Keap1 signaling pathway and oncogene c-myc. It is expected to become a new target for tumor radiotherapy sensitization. Key words: Neoplasms; Radiation tolerance; Ubiquitin specific proteases

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国际肿瘤学杂志

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