{"title":"金针叶提取物对大鼠血清蛋白和肝脏标志物的影响","authors":"Okoyomoh Kingsley, Eberechukwu Lolly Mbanaso, Precious Ebisintei, Elendu Melford Uche","doi":"10.53022/oarjms.2023.5.1.0016","DOIUrl":null,"url":null,"abstract":"The aim of this study was to evaluate the serum protein and hepatomarkers of rats administered ethanol leaf extract of Justicia secunda. Freshly harvested leaves of Justicia secunda were processed into fine powder prior to extraction. Twenty five adult male wistar rats were divided into five rats per group. Group I was the normal control and was only fed with rat chow and water. Groups II-V was anaemia induced. However, while Group II was not administered with extract, Group III and Group IV were administered with 200 and 400 mg/kg of extract respectively and Group V was administered the standard drug. There was no significant (P>0.05) difference between the serum protein (total protein, albumin and globulin) level of rats administered with ethanol leaf extract of J. secunda and that reported for the normal control group. Similar observation was made on the serum hepatomarkers of rats administered the said extract. In conclusion, ethanol leaf extract of J. secunda is not hepatotoxic.","PeriodicalId":19492,"journal":{"name":"Open Access Research Journal of Multidisciplinary Studies","volume":"21 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Serum Proteins and Hepatomarkers of rats treated with Ethanol Leaf Extract of Justicia secunda\",\"authors\":\"Okoyomoh Kingsley, Eberechukwu Lolly Mbanaso, Precious Ebisintei, Elendu Melford Uche\",\"doi\":\"10.53022/oarjms.2023.5.1.0016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of this study was to evaluate the serum protein and hepatomarkers of rats administered ethanol leaf extract of Justicia secunda. Freshly harvested leaves of Justicia secunda were processed into fine powder prior to extraction. Twenty five adult male wistar rats were divided into five rats per group. Group I was the normal control and was only fed with rat chow and water. Groups II-V was anaemia induced. However, while Group II was not administered with extract, Group III and Group IV were administered with 200 and 400 mg/kg of extract respectively and Group V was administered the standard drug. There was no significant (P>0.05) difference between the serum protein (total protein, albumin and globulin) level of rats administered with ethanol leaf extract of J. secunda and that reported for the normal control group. Similar observation was made on the serum hepatomarkers of rats administered the said extract. In conclusion, ethanol leaf extract of J. secunda is not hepatotoxic.\",\"PeriodicalId\":19492,\"journal\":{\"name\":\"Open Access Research Journal of Multidisciplinary Studies\",\"volume\":\"21 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Access Research Journal of Multidisciplinary Studies\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.53022/oarjms.2023.5.1.0016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Access Research Journal of Multidisciplinary Studies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53022/oarjms.2023.5.1.0016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of Serum Proteins and Hepatomarkers of rats treated with Ethanol Leaf Extract of Justicia secunda
The aim of this study was to evaluate the serum protein and hepatomarkers of rats administered ethanol leaf extract of Justicia secunda. Freshly harvested leaves of Justicia secunda were processed into fine powder prior to extraction. Twenty five adult male wistar rats were divided into five rats per group. Group I was the normal control and was only fed with rat chow and water. Groups II-V was anaemia induced. However, while Group II was not administered with extract, Group III and Group IV were administered with 200 and 400 mg/kg of extract respectively and Group V was administered the standard drug. There was no significant (P>0.05) difference between the serum protein (total protein, albumin and globulin) level of rats administered with ethanol leaf extract of J. secunda and that reported for the normal control group. Similar observation was made on the serum hepatomarkers of rats administered the said extract. In conclusion, ethanol leaf extract of J. secunda is not hepatotoxic.
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