肝细胞癌和肝内胆管癌的组织形态学亚型:综述和最新进展

IF 0.1 Q4 PATHOLOGY
Yoon Jung Hwang, Haeryoung Kim
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引用次数: 0

摘要

原发性肝癌是一类异质性肿瘤,主要有肝细胞癌(HCC)和肝内胆管癌(iCCA)两种。在过去的几十年里,HCC和iCCA在形态、分子特征和生物学行为上被认为是异质的,最近世界卫生组织对消化系统肿瘤的分类描述了HCC和iCCA的各种组织形态学亚型,其中一些也具有特征性的分子特征、临床相关性和预后意义。在这篇综述中,我们基于一系列病例,讨论了最近被描述的4种HCC和icca亚型:大梁型HCC、脂肪性HCC、硬化性HCC和小导管icca。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histomorphological Subtypes of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Review and Update
Abstract Primary liver cancers comprise a heterogeneous group of neoplasms, with the 2 main entities being hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Over the past decades, HCC and iCCA have been recognized to be heterogeneous in morphology, molecular features, and biological behavior, and the most recent World Health Organization classification of digestive system tumors describes various histomorphological subtypes of HCC and iCCA, some of which also have characteristic molecular features, clinical correlates, and prognostic implications. In this review, we discuss 4 recently described subtypes of HCC and iCCA—macrotrabecular HCC, steatohepatitic HCC, scirrhous HCC, and small duct iCCA—based on a series of cases.
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