缩聚法制备生物可降解聚合物的研究

G. Papava, I. Chitrekashvili, Marina Gurgenishvili, N. Gelashvili, K. Papava, K. Archvadze
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引用次数: 0

摘要

在土壤破坏性微生物的影响下,空间结构聚合物的生物降解较为复杂,需要较长的时间。我们已经实现了一种聚合物的靶向合成,以获得线性结构的聚合物,其中保留了不稳定的肽键。为了实现聚合物的定向合成并确定反应机理的最佳条件,我们研究了反应的动力学过程及其规律——反应温度、持续时间、组分比、浓度、反应速度常数和活化能。计算了Arrhenius因子和初始组分进入反应介质的先后顺序,确定了催化剂的性质和其他性质。当脲醛摩尔比为1:1时,延长效果较好。在这种情况下,形成线性结构的聚合物,其中保留了肽- ch2 - NH -。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
STUDY OF POLYCONDENSATION PROCESS TO RECEIVE BIODEGRADABLE POLYMERS
Biodegradation of polymers of spatial structure is complicated at the impact of soil destructive microorganisms and biodegradation requires a long time. We have implemented a target-oriented synthesis of a polymer to receive linear structure polymers where labile peptide bonds are preserved. To implement target-oriented synthesis of a polymer and to determine optimal conditions for reaction mechanism we studied the process of kinetics and its regularities – reaction temperature, duration, components ratio, concentration, reaction speed constant, and activation energy. The Arrhenius factor and succession of the introduction of initial components to the reaction medium were computed, and catalyst nature and other properties were determined. A high effect of prolongation was achieved, when carbamide and formaldehyde molar ratio were 1:1. In this case linear structure polymer is formed where peptide -CH2 – NH – are preserved.
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来源期刊
Pharmacy World & Science
Pharmacy World & Science 医学-药学
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