K. I. Grudina, I. Demko, I. V. Putintseva, M. Pesegova, I. Soloveva, A. Kraposhina
{"title":"病理生理方面的“恶性循环”形成的情况下,肝细胞损伤和肝硬化的发展","authors":"K. I. Grudina, I. Demko, I. V. Putintseva, M. Pesegova, I. Soloveva, A. Kraposhina","doi":"10.20333/2500136-2021-1-13-19","DOIUrl":null,"url":null,"abstract":"This review highlights fundamental knowledge about the processes within a damaged liver cell, mechanisms of fi bro- and angiogenesis, as well as hypoxia and hypoxemia. Th e causes and consequences of endothelial dysfunction, the role of cytokines in vascular remodeling and the formation of hemodynamic disorders are described. Th ese changes lead to disorder of local and systemic hemodynamics in case of liver cirrhosis. Such complications as: hepatopulmonary syndrome and portopulmonary hypertension are also described.","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"45 1","pages":"13-19"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Pathophysiological aspects of “vicious circle” formation in case of liver cells damage and cirrhosis development\",\"authors\":\"K. I. Grudina, I. Demko, I. V. Putintseva, M. Pesegova, I. Soloveva, A. Kraposhina\",\"doi\":\"10.20333/2500136-2021-1-13-19\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This review highlights fundamental knowledge about the processes within a damaged liver cell, mechanisms of fi bro- and angiogenesis, as well as hypoxia and hypoxemia. Th e causes and consequences of endothelial dysfunction, the role of cytokines in vascular remodeling and the formation of hemodynamic disorders are described. Th ese changes lead to disorder of local and systemic hemodynamics in case of liver cirrhosis. Such complications as: hepatopulmonary syndrome and portopulmonary hypertension are also described.\",\"PeriodicalId\":17054,\"journal\":{\"name\":\"Journal of Software Maintenance and Evolution: Research and Practice\",\"volume\":\"45 1\",\"pages\":\"13-19\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Software Maintenance and Evolution: Research and Practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20333/2500136-2021-1-13-19\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Software Maintenance and Evolution: Research and Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20333/2500136-2021-1-13-19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pathophysiological aspects of “vicious circle” formation in case of liver cells damage and cirrhosis development
This review highlights fundamental knowledge about the processes within a damaged liver cell, mechanisms of fi bro- and angiogenesis, as well as hypoxia and hypoxemia. Th e causes and consequences of endothelial dysfunction, the role of cytokines in vascular remodeling and the formation of hemodynamic disorders are described. Th ese changes lead to disorder of local and systemic hemodynamics in case of liver cirrhosis. Such complications as: hepatopulmonary syndrome and portopulmonary hypertension are also described.