求解赫胥黎方程的神经网络

B. Milićević, M. Ivanovic, B. Stojanovic, Nenad Filipović
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引用次数: 0

摘要

生物物理肌肉模型,又称赫胥黎模型,适用于模拟非均匀非定常收缩。大规模模拟使用起来可能更具挑战性,因为这种类型的模型可能需要大量的计算。特征方法通常用于求解赫胥黎肌肉方程,该方程描述了肌动蛋白结合位点连接的肌凝蛋白头的分布。求解该方程后,我们可以确定产生的力和肌纤维的刚度,然后可以用于有限元分析的宏观模拟。在我们的论文中,我们开发了一个物理信息代理模型,其功能与原始赫胥黎肌肉模型相似,但使用的计算资源要少得多,以便更有效地利用赫胥黎肌肉模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NEURAL NETWORKS FOR SOLVING HUXLEY’S EQUATION
Biophysical muscle models, also known as Huxley-type models, are appropriate for simulating non-uniform and unsteady contractions. Large-scale simulations can be more challenging to use because this type of model can be computationally intensive. The method of characteristics is typically used to solve Huxley’s muscle equation, which describes the distribution of connected myosin heads to the actin-binding sites. Once this equation is solved, we can determine the generated force and the stiffness of the muscle fibers, which may then be employed in the macro-level simulations of finite element analysis. In our paper, we developed a physics-informed surrogate model that functions similarly to the original Huxley muscle model but uses a lot less computational resources in order to enable more effective use of the Huxley muscle model.
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