也门城市病毒性肝炎的血清分子流行病学和危险因素

B.A.H. Al Nabehi, H. A. Shamahy, W. Saeed, E. G. Khalil, A. Musa, Ahmed M. ElHasssan
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引用次数: 12

摘要

病毒性肝炎是一种急性或慢性被忽视的疾病,主要影响肝脏。本研究旨在确定也门城市地区病毒性肝炎和丙型肝炎基因型的血清患病率和危险因素。在一项前瞻性、横断面、分析性和基于社区的研究中,根据知情同意,随机招募了501名志愿者。收集了人口统计学和临床数据。采用ELISA法进行HBV、HDV、HCV筛查。使用COBAS TaqMan48分析仪(Roche Diagnostics Gmbh, Germany)进行HBV/HCV病毒载量和HCV基因分型。研究人群的平均年龄为25.9±10.6岁,男女比例为1。萨那、塔伊兹和亚丁的HBV血清患病率相似(p = 0.2)。与萨那(5.4%)相比,亚丁和塔伊兹过去HBV感染的证据(分别为14.1%和18.8%)显著高(p = 0.002)。HBV DNA病毒载量变化很大(1350和6320拷贝mLG)。HCV血清患病率较低,研究城市间无显著差异(p = 0.4)。HCV病毒载量在不同的样本之间差异很大(657300-1630000拷贝mLG)。HCV基因型4和1a是最主要的基因型。输血(19%)、肾透析(18.6%)、拔罐史(18.1%)、外科手术(17.4%)和牙科治疗(15.4%)是HBV和HCV血清反应性最常见的危险因素。总之,也门不同地理区域的HBV血清流行率是不同的。既往HBV暴露率高。输血和被污染的手术器械是病毒性肝炎的重要感染风险。HCV基因型4和1a最为普遍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sero-Molecular Epidemiology and Risk Factors of Viral Hepatitis in Urban Yemen
Viral hepatitis is an acute or chronic neglected disease that affects predominantly the liver. This study aimed to determine the sero prevalence and risk factors for viral hepatitis and HCV genotypes in urban areas of Yemen. In a prospective, cross-sectional, analytical and community-based study and following informed consent, 501 volunteers were randomly recruited. Demographic and clinical data was collected. Screening for HBV, HDV and HCV was carried out using ELISA. HBV/HCV viral loads and HCV genotyping were carried out using COBAS TaqMan48 Analyzer (Roche Diagnostics Gmbh, Germany). The mean age of study population was 25.9±10.6 years with a male: female ratio of 1. HBV sero prevalence was similar in Sana'a, Taiz and Aden (p = 0.2). Evidence of past HBV infection was significantly high in Aden and Taiz (14.1 and 18.8%, respectively) compared to Sana’a (5.4%) (p = 0.002). HBV DNA Viral loads were widely variable (1350 and 6320 copies mLG). HCV sero prevalence was low and not significantly different in the study cities (p = 0.4). HCV Viral loads were widely variable between samples (657300-1630000 copies mLG). HCV Genotypes 4 and 1a were the most predominant genotypes. Blood transfusion (19%), renal dialysis (18.6%), history of cupping (18.1%), surgical operation (17.4%) and dental treatment (15.4%) were the most common risk factors for HBV and HCV sero reactivity. In conclusion, HBV sero prevalence is variable among different geographical areas in Yemen. Past exposure to HBV is high. Blood transfusion and contaminated surgical instruments are important infection risks for viral hepatitis. HCV genotypes 4 and 1a are the most prevalent.
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