间歇式和混区流动注射法测定盐酸四环素的含量

Q2 Chemistry

Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2023.6.001

Esraa Rasool Radhi, K. Ali, Fatima Hydar Abdul Hussein

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引用次数: 1

摘要

本研究的目的是建立灵敏、准确的盐酸四环素的定量和混区流动注射方法。方法取决于所研究的药物在碱性介质中与高锰酸钾氧化，并在610 nm处测量绿色氧化产物的吸光度。在0.5 ~ 25 μg mL−1和1 ~ 25 μg mL−1的浓度范围内，两种方法的校准曲线均呈线性关系。计算了比吸收系数和摩尔吸收系数、检测限和定量限以及桑德尔灵敏度。建议的方法进一步应用于药物制剂中四环素的定量测定。

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Batch and merging-zone flow injection methods for determination of tetracycline hydrochloride

The objective of the present work is to develop batch and merging-zone flow injection methods for sensitive and accurate spectrophotometric determination of tetracycline hydrochloride. The methods depend on the oxidation of the studied drug with potassium permanganate in an alkaline medium, and the absorbance of the green oxidation product was measured at 610 nm. The calibration graphs in both procedures were linear in the concentration ranges of 0.5 – 25 and 1 – 25 μg mL−1 using the spectrophotometric and merging-zone flow injection methods, respectively. Specific and molar absorption coefficients, limits of detection and quantification, and Sandell’s sensitivity were calculated. The suggested procedures were further applied to the quantitative determination of tetracycline in pharmaceutical formulations.

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The "Current Chemistry Letters" is a peer-reviewed international journal which aims to publish all the current and outstanding research articles, reviews and letters in chemistry including analytical chemistry, green chemistry, inorganic chemistry, organic chemistry, physical chemistry, etc. This journal is dedicated to serve all academic and industrial researchers and scientists who are expert in all major advances in chemistry research. The journal aims to provide the most complete and reliable source of information on current developments in these fields. The emphasis will be on publishing quality articles rapidly and openly available to researchers worldwide. Please note readers are free to read, download, copy, distribute, print, search, or link to the full texts of articles published on this journal. Current Chemistry Letters is an open access journal, which provides instant access to the full text of research papers without any need for a subscription to the journal where the papers are published. Therefore, anyone has the opportunity to copy, use, redistribute, transmit/display the work publicly and to distribute derivative works, in any sort of digital form for any responsible purpose, subject to appropriate attribution of authorship. Authors who publish their articles may also maintain the copyright of their articles.