牛初乳免疫球蛋白G1在葡聚糖上的特异性吸附及其对小鼠脾细胞的有丝分裂活性

M. Miura, Tadao Saito, H. Kitazawa, T. Itoh, T. Inamoto
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引用次数: 5

摘要

分娩后的牛初乳含有高浓度的免疫球蛋白(Ig),其中95%以上为1型IgG,对牛新生儿建立被动免疫至关重要。众所周知,牛初乳含有多种生物活性成分。然而,影响免疫系统中细胞生长的成分尚不清楚。众所周知,从豆角(Canavalia ensiformis)中提取的番豆蛋白A (cona)能凝集多种动物的红细胞2),并对小鼠T淋巴细胞具有促丝活性。3)cona已通过Sephadex凝胶的单一亲和层析分离得到。4)1983年,Shimada等人报道了牛血浆中部分fig与Sephadex的特异性结合。从Con A和牛血清Ig在与Sephadex结合方面的相似特性来看,我们怀疑某些牛血清Ig与Sephadex的结合具有相似性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Specific Adsorption of Immunoglobulin G1 in Bovine Colostrum on Sephadex and Its Mitogenic Activity on Mouse Splenocytes
Bovine colostrum immediately after parturition contains a high concentration ofimmunoglobulin (Ig) in which 95% or more are IgG type1} and it is important for the bovine neonate to establish passive immunity. It is also known that bovine colostrum contains various biologically active components. However, components that affect the growth of the cells involved in the immunesystem are not known. It is known that Concanavalin A (Con A) from jack beans (Canavalia ensiformis) agglutinates erythrocytes of various animal species2) and has mitogenic activity for mouse T lymphocytes.3) Con A has been isolated by a single affinity chromatography on Sephadex gel.4) In 1983, Shimada et al.5) have reported the specific binding of a part ofIg in bovine plasma to Sephadex. From the similar properties of Con A and bovine serum Ig with respect to binding to Sephadex, we suspected that certain bovine
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