结晶条件对莫达非尼物质多态性的影响

Q4 Chemistry
E. G. Karankevich, Z. Kuvaeva, L. Kulbitskaya, A. Popov
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引用次数: 0

摘要

用x射线粉末衍射法研究了甲醇溶液中莫达非尼结晶条件对产物多晶态的影响。实验结果表明,冷却速率和饱和溶液浓度的变化对得到的莫达非尼样品的衍射特性有影响。此外,冷却速度实际上并不影响结晶产品的产率,这取决于结晶溶液的饱和程度。研究发现,在浓度为0.34 ~ 0.44 M的莫达非尼溶液中,缓慢冷却可获得I型莫达非尼的多晶形态,主要是温度梯度为5 ~ 10℃/h至5±2℃。饱和溶液冷却速率的增加和饱和溶液浓度>0.44 M导致莫达非尼晶体的混合多晶形式的产生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of crystallization conditions on modafinil substance polymorphism
The effect of the crystallization conditions of modafinil from its methanol solutions on the polymorphic state of the resulting substance was studied using the X-ray powder diffraction method. It is shown that changes in the cooling rate and the concentration of saturated solutions have an effect on obtaining samples of the modafinil substance with differences in diffractometric characteristics. Moreover, the cooling rate practically does not affect the yield of the crystalline product, which depends on the degree of saturation of crystallization solutions. It was found that the I polymorphic form of modafinil can be obtained from modafinil solutions with a concentration in the range of 0.34–0.44 M with slow cooling of solutions, mainly with a temperature gradient of 5–10 °C/hour to a temperature of 5 ± 2 °C. An increase in the cooling rate of saturated solutions and their concentration >0.44 M leads to the production of mixed polymorphic forms of modafinil crystals.
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来源期刊
CiteScore
0.30
自引率
0.00%
发文量
38
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