急性缺血性脑卒中和出血性脑卒中入院高血糖与严重程度和30天预后关系的研究:一项比较横断面研究

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
O. Agabi, O. Ojo, M. Danesi, F. Ojini, N. Okubadejo
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引用次数: 0

摘要

背景:高血糖在急性脑卒中中被认为是有害的,尽管其影响可能因脑卒中亚型而异。我们试图确定入院时高血糖的频率(亚分类为糖尿病相关或反应性),并探讨急性缺血性卒中(AIS)和脑出血(ICH)卒中亚型与卒中严重程度和功能运动结局的关系。方法:本横断面研究招募170例脑卒中患者(85例AIS, 85例ICH),发病72小时内出现。基线特征包括中风严重程度(美国国立卫生研究院卒中量表评分)、随机血糖(RBG)和糖化血红蛋白(HBA1C)。结果为30天病死率(CFR)和功能运动结果。结果:AIS患者入院高血糖发生率为24.7%,脑出血患者入院高血糖发生率为22.4%,其中AIS患者为18.8%/5.9%,脑出血患者为9.4%/12.9%。AIS患者脑卒中严重程度和梗死面积与入院时RBG和HBA1C呈正相关(P = 0.000),而ICH患者不呈正相关。推测的高血糖机制与梗死面积或血肿体积均无显著相关性(P < 0.05)。伴有高血糖的AIS患者的30天CFR(42.9%)高于血糖正常者(12.5%)(P = 0.003),但ICH患者的30天CFR差异不显著(伴有高血糖者为42.1%,无高血糖者为36.4%;P = 0.65)。在两种脑卒中亚型中,高血糖与功能结局均无显著关系。结论:入院时高血糖与急性脑卒中严重程度和短期病死率的关系在AIS患者中是明显的。在脑出血患者中,尽管高血糖患者的病死率更高,但高血糖与卒中严重程度和30天死亡没有显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An investigation of the relationship of the admission hyperglycemia to severity and 30-day outcome in acute ishemic and intracerebral hemorraghic stroke: A comparative cross sectional study
Background: Hyperglycemia is implicated as deleterious in acute stroke, although the impact may vary by stroke subtype. We sought to determine the frequency of admission hyperglycemia (subcategorized as diabetes related or reactive) and explore the relationship to stroke severity and functional motor outcome in acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) stroke subtypes. Methods: This cross-sectional study recruited 170 stroke patients (85 AIS, 85 ICH) presenting within 72 h of onset. Baseline characteristics including stroke severity (National Institutes of Health Stroke Scale score), random blood glucose (RBG), and glycated hemoglobin (HBA1C) were documented. The outcomes were 30-day case fatality rate (CFR) and functional motor outcome. Results: The frequency of admission hyperglycemia was 24.7% in AIS and 22.4% ICH, with 18.8%/5.9% of AIS and 9.4%/12.9% of ICH presumed diabetes related and reactive, respectively. Stroke severity and infarct size were positively correlated with admission RBG and HBA1C (P = 0.000) in AIS but not ICH. Presumed mechanism of hyperglycemia did not relate significantly with either infarct size or hematoma volume (P > 0.05). Thirty days CFR was higher in AIS with hyperglycemia (42.9%) compared to normoglycemia (12.5%) (P = 0.003), but did not vary significantly in ICH (42.1% with and 36.4% without hyperglycemia; P = 0.65). There was no significant relationship of hyperglycemia to functional outcome in either stroke subtype. Conclusions: The association of admission hyperglycemia to stroke severity and short-term case fatality is evident in AIS. In ICH, hyperglycemia was not associated with significantly greater stroke severity and death at 30 days, even though case fatality was higher in those with hyperglycemia.
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来源期刊
Journal of Clinical Sciences
Journal of Clinical Sciences MEDICINE, GENERAL & INTERNAL-
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审稿时长
45 weeks
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