银屑病:斑块型银屑病的发病机制及长期治疗进展综述

T. Gmeiner, J. Grželj, B. Strukelj, Luka Stopar, P. Marko
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引用次数: 2

摘要

银屑病的治疗已经发生了巨大的变化,包括成功的全身炎症治疗和银屑病患者的教育。本文的重点是利用药物遗传学和生物标志物鉴定提供的最新见解,了解牛皮癣的病因,其合并症的意义,治疗可能性和长期管理的最新进展。疾病的成功控制导致心肌梗死和长期心血管风险的减少,但通常是在各种治疗尝试之后实现的,直到确定最适合个体的治疗方法。揭示与疾病预后、合并症、治疗反应和不良反应相关的生物标志物是一个高度未满足的医学需求。必须进行更多的研究来鉴定和验证生物标志物,并在临床实践中实施个性化医疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Psoriasis: A Comprehensive Review on the Aetiopathogenesis and Recent Advances in Long-Term Management of Patients with Plaque Psoriasis
Immense changes have been introduced in psoriasis treatment, including successful systemic treatment of inflammation and education of psoriatic patients. The focus of this review is the latest developments in the understanding of the aetiopathogenesis of psoriasis, the significance of its comorbidities, treatment possibilities and long-term management using the latest insight provided by pharmacogenetics and identification of biomarkers. The successful control of the disease leads to reduction of myocardial infarction and long-term cardiovascular risk but is usually achieved after various therapeutic attempts until the best-matched treatment for the individual is identified. There is a high unmet medical need for revealing biomarkers associated with disease prognosis, comorbidities, response to therapy and adverse effects. More studies have to be performed for identification and validation of biomarkers and implementation of personalized medicine into clinical practice.
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