J.A. Schwarz , G. Harbauer, R. Hofmann, H.-J. Wilhelm, H. Lutz
{"title":"水里有抑制免疫的作用","authors":"J.A. Schwarz , G. Harbauer, R. Hofmann, H.-J. Wilhelm, H. Lutz","doi":"10.1016/S0300-872X(76)80025-X","DOIUrl":null,"url":null,"abstract":"<div><p>Following immunization against sheep erythrozytes, it is possible to induce a double-peaked antibody response curve in the serum of experimental animals (rats) by using vincristine sulfate (Vi). Immunosuppression is enhanced in thymectomised and sensitised animals during rechallenge following Vi/Cy, as compaired to animals treated with cyclophosphamide (Cy) alone, and an attenuated anamnestic reaction is subsequently observed.</p><p>Survival time of allogeneic skin grafts in colony bred and inbred rat strains could not be prolonged by using Vi/Cy, as compaired to animals treated with Cy alone.</p></div>","PeriodicalId":101289,"journal":{"name":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","volume":"151 4","pages":"Pages 305-315"},"PeriodicalIF":0.0000,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0300-872X(76)80025-X","citationCount":"0","resultStr":"{\"title\":\"Kombinierte Immunsuppression mit Vincristinsulfat and Cyclophosphamid\",\"authors\":\"J.A. Schwarz , G. Harbauer, R. Hofmann, H.-J. Wilhelm, H. Lutz\",\"doi\":\"10.1016/S0300-872X(76)80025-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Following immunization against sheep erythrozytes, it is possible to induce a double-peaked antibody response curve in the serum of experimental animals (rats) by using vincristine sulfate (Vi). Immunosuppression is enhanced in thymectomised and sensitised animals during rechallenge following Vi/Cy, as compaired to animals treated with cyclophosphamide (Cy) alone, and an attenuated anamnestic reaction is subsequently observed.</p><p>Survival time of allogeneic skin grafts in colony bred and inbred rat strains could not be prolonged by using Vi/Cy, as compaired to animals treated with Cy alone.</p></div>\",\"PeriodicalId\":101289,\"journal\":{\"name\":\"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie\",\"volume\":\"151 4\",\"pages\":\"Pages 305-315\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0300-872X(76)80025-X\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0300872X7680025X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300872X7680025X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Kombinierte Immunsuppression mit Vincristinsulfat and Cyclophosphamid
Following immunization against sheep erythrozytes, it is possible to induce a double-peaked antibody response curve in the serum of experimental animals (rats) by using vincristine sulfate (Vi). Immunosuppression is enhanced in thymectomised and sensitised animals during rechallenge following Vi/Cy, as compaired to animals treated with cyclophosphamide (Cy) alone, and an attenuated anamnestic reaction is subsequently observed.
Survival time of allogeneic skin grafts in colony bred and inbred rat strains could not be prolonged by using Vi/Cy, as compaired to animals treated with Cy alone.
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