肝素烯丙基酯、肝素4-乙烯基苄基酯与依诺肝素的硫烯反应

Reactions Pub Date : 2022-09-05 DOI:10.3390/reactions3030031
R. Taylor, D. Poudel
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引用次数: 0

摘要

制备了肝素烯丙基酯和肝素4-乙烯基苄基酯,并利用自由基引发剂和光化学方法研究了它们在巯基反应中的潜力。虽然两者都与巯基乙酸发生反应,但烯丙基酯加合物被证明更不稳定。还报道了肝素4-乙烯基苄基酯加合物的几个例子。在依诺肝素上也有类似的反应,其反应位点仅在分子的非还原端,也有报道。这些反应可能在药物偶联物的开发策略中显示出希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thiol-Ene Reaction of Heparin Allyl Ester, Heparin 4-Vinylbenzyl Ester and Enoxaparin
Heparin allyl ester and heparin 4-vinylbenzyl ester were prepared and examined for their potential for thiol-ene reaction using both free radical initiators and photochemistry. While both undergo reaction with mercaptoacetic acid, the allyl ester adduct proved to be somewhat more labile. Several more examples of adducts from heparin 4-vinylbenzyl ester are reported. Similar reactions on enoxaparin, where the reaction site is solely at the non-reducing end of the molecule, are also reported. These reactions may show promise as a strategy in the development of drug conjugates.
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来源期刊
CiteScore
2.70
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