Association of serum uric acid with markers of inflammations And disease severity in ankylosing spondylitis patients

Objective: To clarify the relationships between Serum uric acid with inflammatory laboratory markers and Ankylosing Spondylitis Disease Activity Score (ASDAS-ESR) in patients with ankylosing spondylitis. Method: A total of 73 ankylosing spondylitis patients with age ≥ 16 years with AS fulfilling ASAS criteria were included in a cross-sectional study. The laboratory measures included values of uric acid, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) obtained. Disease activity is calculated by Ankylosing Spondylitis Disease Activity Score (ASDAS-ESR). Demographic and laboratory investigations were recorded. Results: The mean age of the studied sample was 35.04 ± 7.99 years with a range of (17-52 years) & the mean Body Mass Index was 27.91 ± 5.78 with a range (18-46). The majority of them were married (80.8%), working (94.5%), and non-smokers (52.1%) and (94.5%) on biological therapy. Comparing serum uric acid with ESR value revealed no statically significant association (P = 0.47). Again, this is observed when comparing serum uric acid with CRP Value (P = 0.27). Finally, there was no association between Serum uric acid with any level of disease activity measured through ASDAS-ESR score (P = 0.52). Conclusion : The study concludes that there is no association between Serum uric acid and the routine inflammatory markers and Ankylosing Spondylitis disease activity score (ASDAS-ESR).