肯尼亚Kiambu县商业家禽生产系统中分离的选定肠杆菌科抗微生物药物耐药性模式

Pharmacology & Pharmacy Pub Date : 2021-01-01 DOI:10.4236/pp.2021.1210019

J. Ndukui, J. Gikunju, G. Aboge, J. Mwaniki, S. Kariuki, J. Mbaria

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引用次数: 0

摘要

导言:在过去的二十年中，肠道感染的治疗因耐药菌株的出现而变得复杂。产生多药耐药扩展谱β -内酰胺酶(ESBL)的肠杆菌科细菌的出现，使发展中国家的发病率和死亡率提高了6倍，对公众健康构成了最大的威胁。本研究旨在确定从Kiambu县商业家禽生产系统中分离的选定肠杆菌科细菌的抗生素耐药性模式。方法:于2020年10月至2021年2月在坚布县6个区县进行实验室横断面研究。每户共收集粪便样本437份。对大肠杆菌采用纸片扩散法进行药敏试验;沙门氏菌许可证。志贺氏杆菌许可证。和克雷伯氏菌。通过标准生化分离鉴定。结果:在收集的437份粪便和粪便样本中，分离出591株，其中大肠杆菌(48.9%)是最常见的，其次是志贺氏菌。(18.8%)，沙门氏菌。(18.3%)和克雷伯氏菌。(14.0%)。该研究表明，分离株中存在较高的多重耐药率，特别是对磺胺甲恶唑(79%)、甲氧苄啶(71%)和四环素(59%)的耐药率。此外，这些分离株对头孢噻肟(94%)、庆大霉素(93%)和头孢曲松(91%)的敏感性最高。如何引用本文:Ndukui, j.g.， Gikunju, j.k.， Aboge, g.o.， Mwaniki, J.， Kariuki, S.和Mbaria, J.M.(2021)肯尼亚Kiambu县商业家禽生产系统中分离的部分肠杆菌科抗生素耐药性模式。药理学与药学，12,219-236。https://doi.org/10.4236/pp.2021.1210019收稿日期:2021年8月12日收稿日期:2021年10月22日出版日期:2021年10月25日版权所有©作者与科研出版公司。本作品采用知识共享署名国际许可协议(CC BY 4.0)。http://creativecommons.org/licenses/by/4.0/开放获取

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Antimicrobial Resistance Patterns of Selected Enterobacteriaceae Isolated from Commercial Poultry Production Systems in Kiambu County, Kenya

Introduction: In the last two decades, the treatment of enteric infections has been complicated by the emergence of antimicrobial resistant strains. Occurrence of multidrug resistant Extended Spectrum Beta Lactamase (ESBL) producing Enterobactaeraceae poses the greatest risk to public health by raising morbidity and mortality by six folds in developing countries. The present study aims to determine the antibiotics resistance patterns of selected Enterobacteriaceae isolated from commercial poultry production systems in Kiambu County. Methods: A laboratory based cross-sectional study was conducted in six purposively selected Sub-Counties of Kiambu County from October 2020, to February 2021. A total of 437 fecal samples were collected from each household. The antibiotic susceptibility testing using disk diffusion method was used against E. coli; Salmonella spps.; Shigella spps.; and Klebsiella spps. which were isolated and identified through standard biochemical. Results: Out of 437 fecal and stool samples collected, 591 isolates were recovered with E. coli (48.9%) being the most frequently identified, followed by Shigella spps. (18.8%), Salmonella spps. (18.3%), and Klebsiella spps. (14.0%). The study shows there was high prevalence of multiple resistance among isolates especially to Sulfamethoxazole (79%), Trimethoprim (71%), and Tetracyclines (59%), correspondingly. Additionally, the isolates showed the highest rate of susceptibility against Cefuroxime (94%), Gentamicin (93%), Ceftriaxone (91%), How to cite this paper: Ndukui, J.G., Gikunju, J.K., Aboge, G.O., Mwaniki, J., Kariuki, S. and Mbaria, J.M. (2021) Antimicrobial Resistance Patterns of Selected Enterobacteriaceae Isolated from Commercial Poultry Production Systems in Kiambu County, Kenya. Pharmacology & Pharmacy, 12, 219-236. https://doi.org/10.4236/pp.2021.1210019 Received: August 12, 2021 Accepted: October 22, 2021 Published: October 25, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access

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Pharmacology & Pharmacy

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