总睾酮水平可能对30 - 60岁男性2型糖尿病患者勃起功能障碍的发生和严重程度没有影响

IF 0.6 Q4 ENDOCRINOLOGY & METABOLISM
Martine Claude Etoa Etoga, Doris Bibi Essama, A. Mbassi, J. Nkeck, Francine Mendane Mekobe, M. Dehayem, A. Vicky, E. Sobngwi, J. Mbanya
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Erectile dysfunction was assessed using the IIEF-5 questionnaire. Total testosterone was measured by ELISA. The relationship between erectile dysfunction and total testosterone has been explored through correlation using Pearson’s coefficient. The significance threshold was set at 0.05. Results: A total of 83 participants were included, with an average age of 47.9 ± 7.8 years. The median duration of diabetes was 24 (5; 72) months. The frequency of ED was 65.1%, severe for 50% of cases and significantly associated with the duration of diabetes (OR = 7.5 [2.4; 22.8]). The mean testosterone level was 14.3 ± 5.1 nmol/l. A low level of testosterone was found in 8.4% (7/83) of participants, and sedentary lifestyle was significantly associated with low testosterone level (OR = 4.1 [1; 15.4]). There was no difference between the mean total testosterone level of patients with ED (14.1 ± 4.7 nmol/l) and those without (14.3 ± 5.9 nmol/l) (p = 0.8). 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引用次数: 0

摘要

背景:勃起功能障碍是2型糖尿病患者最常见的性功能障碍。其发病机制可能涉及多种障碍,包括内皮功能障碍和自主神经异常。低睾丸激素水平的参与仍然存在争议。本研究的目的是评估总睾酮在2型糖尿病患者勃起功能障碍中的作用。方法:在雅温市中心医院国家肥胖中心对年龄在30-60岁的2型糖尿病男性患者进行横断面研究。排除可能影响睾酮水平的非糖尿病性疾病。使用IIEF-5问卷评估勃起功能障碍。ELISA法测定总睾酮水平。勃起功能障碍与总睾酮之间的关系已通过Pearson 's系数进行了相关性研究。显著性阈值设为0.05。结果:共纳入83例患者,平均年龄47.9±7.8岁。糖尿病的中位病程为24 (5;72)个月。ED发生率为65.1%,重症发生率为50%,且与糖尿病病程显著相关(OR = 7.5 [2.4;22.8])。平均睾酮水平为14.3±5.1 nmol/l。8.4%(7/83)的参与者睾酮水平较低,久坐的生活方式与低睾酮水平显著相关(OR = 4.1;15.4])。ED患者平均总睾酮水平(14.1±4.7 nmol/l)与非ED患者(14.3±5.9 nmol/l)差异无统计学意义(p = 0.8)。总睾酮水平与IIEF-5评分无相关性(r = - 0.05;p = 0.5)。结论:三分之二的2型糖尿病患者存在勃起功能障碍,其中一半患者的勃起功能障碍较为严重。总睾酮水平似乎对60岁以下2型糖尿病男性ED的发病或严重程度没有影响,但它与久坐的生活方式有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Total testosterone level may have no influence on the occurrence and severity of erectile dysfunction in males aged between 30 and 60 years living with type 2 diabetes
Background: Erectile dysfunction is the most common sexual disorder in type 2 diabetes. Its pathogenesis may involve various disturbances including endothelial dysfunction and dysautonomia. The involvement of a low testosterone level is still debated. The aim of this study was to evaluate the contribution of total testosterone during erectile dysfunction in patients living with type 2 diabetes. Method: A cross-sectional study was conducted in a population of male with type 2 diabetes, aged 30–60 years, and enrolled at the National Obesity Centre of the Yaoundé Central Hospital. Non-diabetic conditions that could affect testosterone level were excluded. Erectile dysfunction was assessed using the IIEF-5 questionnaire. Total testosterone was measured by ELISA. The relationship between erectile dysfunction and total testosterone has been explored through correlation using Pearson’s coefficient. The significance threshold was set at 0.05. Results: A total of 83 participants were included, with an average age of 47.9 ± 7.8 years. The median duration of diabetes was 24 (5; 72) months. The frequency of ED was 65.1%, severe for 50% of cases and significantly associated with the duration of diabetes (OR = 7.5 [2.4; 22.8]). The mean testosterone level was 14.3 ± 5.1 nmol/l. A low level of testosterone was found in 8.4% (7/83) of participants, and sedentary lifestyle was significantly associated with low testosterone level (OR = 4.1 [1; 15.4]). There was no difference between the mean total testosterone level of patients with ED (14.1 ± 4.7 nmol/l) and those without (14.3 ± 5.9 nmol/l) (p = 0.8). No association was found between total testosterone level and IIEF-5 score (r = −0.05; p = 0.5). Conclusion: Erectile dysfunction occurs in two out of three people living with type 2 diabetes and is severe for half of the cases. Total testosterone level does not seem to have an influence on the onset or severity of ED in male under 60 years with type 2 diabetes, but it is associated with a sedentary lifestyle.
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