人非翻译含铝RNA的分子克隆及序列分析

DNA Sequence Pub Date : 2001-01-01 DOI:10.3109/10425170109042055

S. Kwok, I. Daskal

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摘要

在LNCaP细胞中不表达，而在正常人前列腺中表达，通过减法杂交鉴定出LNX1 cDNA。序列分析显示，该序列包含两个Alu重复序列，但没有长开放阅读框。因此，它属于一类未翻译的含铝rna。LNX1在大多数组织中表达。它由位于人类第14号染色体上的单个复制基因编码。

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Molecular Cloning and Sequence Analysis of a Human Untranslated Alu-Containing RNA

A cDNA, designated LNX1, has been identified by subtractive hybridization on the basis that it is expressed in normal human prostate but not in LNCaP cells. Sequence analysis revealed that it contained two Alu repetitive sequences but no long open reading frame. Hence, it belongs to a class of untranslated Alu-containing RNAs. LNX1 is expressed in most tissues. It is encoded by a single copy gene, which is localized on human chromosome 14.

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DNA Sequence

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