Overlapping Metabolic and Endocrine Dysfunction during Wolff ParkinsonWhite Syndrome: A Cause or Consequence?

In North America and globally, 1 out of 10 people suffer from orphan/rare diseases. Among these patients which are mostly children, 30% of the children die within the first decade. According to National Organization for Rare Disease database (NORD), there are around approximately 7000 rare diseases (https://rarediseases.org). This view point would definitely shed light into the importance of metabolic and endocrine abnormalities that co-exist with a rare disease. Some of the rare diseases which have been shown to be accompanied by metabolic abnormalities include Bartter’s syndrome, Schindler disease, Incontinentia Pigmenti, Cystinosis, Marfan disease and Wolff Parkinson White syndrome. This article will specially focus on the cardiovascular complicationWPW syndrome.