球囊血管成形术联合支架植入术治疗肾移植动脉狭窄的近期和远期效果

A. Shabunin, P. Drozdov, V. Tsurkan, I. Nesterenko, D. A. Makeev, O. S. Zhuravel, S. А. Astapovich, I. A. Zyablikov
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引用次数: 0

摘要

的目标。目的评价经皮腔内球囊血管成形术联合支架置入术治疗肾移植动脉狭窄的安全性和有效性。材料和方法。从2018年6月到2022年12月,在城市临床医院n.a. S.P. Botkin的外科诊所进行了344例来自已故捐赠者的肾脏移植手术。该研究组包括220名男性(63.9%)和124名女性(36.1%)。平均年龄46.46±11.74(19-73)岁。平均随访20.05(1-54)个月,4例(1.16%)诊断为肾移植动脉狭窄。从移植到诊断狭窄的平均时间为4(1-9)个月。此外,我们还在其他中心的4例肾移植受者中诊断出该并发症的发展。这些患者从移植到诊断狭窄的平均时间为103.25(12-221)个月。因此,我们有8例肾移植动脉狭窄的治疗经验:4例男性(50%)和4例女性(50%)。平均年龄为48.25±11.97(27 ~ 60)岁。狭窄表现为肾移植功能不全,尿素和肌酐进行性升高6例(75%),动脉高血压2例(25%)。诊断狭窄时肌酐平均水平为290.75(157-494)µmol/L,肾小球滤过率为22.87±12.19 (8-41)ml/min/1.73m2。结果。术后早期出现1例并发症,为股总动脉搏动性血肿,需手术治疗(Clavien-Dindo分级为IIIA)。术后平均住院天数为5.22(4-8)。平均随访时间22.75±7.4(14-33)个月。所有接受者在整个随访期间都存活。8名受者中有7名(87.5%)移植物功能正常,1名患者出现进行性移植物功能障碍,为此开始慢性血液透析。移植物功能正常的受者肌酐平均值为156.71±33.4(123-200)µmol/L;平均肾小球滤过率为41.57 ml/min/1.73m2。结论。经皮腔内球囊血管成形术联合支架置入术是一种安全、有效的微创技术,是肾移植动脉狭窄的首选手术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immediate and long-term results of the use of balloon angioplasty with stenting in the treatment of renal graft arterial stenosis
Aim. To assess the safety and efficacy of percutaneous transluminal balloon angioplasty with stenting for renal graft artery stenosis. Material and methods. From June 2018 to December 2022, 344 kidney transplants from a deceased donor were performed at the surgical clinic of City Clinical Hospital n.a. S.P. Botkin. The study group consisted of 220 men (63.9%) and 124 women (36.1%). The mean age was 46.46±11.74 (19–73) years. With a mean follow-up period of 20.05 (1-54) months, stenosis of the renal graft artery was diagnosed in 4 patients (1.16%). The mean time from transplantation to the diagnosis of stenosis was 4 (1–9) months. In addition, we diagnosed the development of this complication in 4 kidney transplant recipients operated in other centers. The mean time from transplantation to the diagnosis of stenosis in these patients was 103.25 (12–221) months. Thus, we have the experience in the treatment of renal transplant arterial strictures in 8 recipients: 4 men (50%) and 4 women (50%). The mean age was 48.25±11.97 (27–60) years. Stenosis was manifested by renal graft dysfunction with a progressive increase in urea and creatinine in 6 patients (75%), by arterial hypertension in 2 patients (25%). The mean, level of creatinine at the time of diagnosing stenosis was 290.75 (157–494) µmol/L, glomerular filtration rate was 22.87±12.19 (8–41) ml/min/1.73m2 . Results. In the early postoperative period, 1 complication was recorded in the form of pulsating hematoma of the common femoral artery, which required surgical intervention (complication class IIIA according to Clavien-Dindo). The mean hospital postoperative bed-days made 5.22 (4-8). The mean follow-up time was 22.75±7.4 (14–33) months. All recipients were alive throughout the whole follow-up period. In 7 of 8 recipients (87.5%), the graft was functioning, in 1 patient a progressive graft dysfunction was noted, for which chronic hemodialysis was started. Mean creatinine in recipients with a functioning graft was 156.71±33.4 (123–200) µmol/L; mean glomerular filtration rate was 41.57 ml/min/1.73m2 . Conclusions. Percutaneous transluminal balloon angioplasty with stenting is a safe and effective minimally invasive technique and should be considered as the operation of choice in the development of renal graft artery stenosis.
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