在链脲佐菌素-烟酰胺诱导的糖尿病大鼠中,补充胡萝卜加干酪可通过其抗氧化潜力减轻糖尿病

P. Nivedha, V. Uddandrao, G. Saravanan, P. Brahmanaidu, S. Vadivukkarasi
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摘要

背景:理想的治疗糖尿病的药物应该是不良反应少或无不良反应,因此筛选植物性产品的抗糖尿病活性是迫切需要的。印度奶酪是基本的营养和完整的本地乳制品,天然产品中加入了印度奶酪,大大增加了其治疗潜力。目的:探讨胡萝卜掺入奶酪(CIP)对链脲霉素(STZ)和烟酰胺(NAD)诱导的糖尿病大鼠血糖、体重、胰岛素以及酶抗氧化剂如超氧化物歧化酶、过氧化氢酶、谷胱甘肽(GSH)过氧化物酶和降低谷胱甘肽的影响。材料与方法:将糖尿病大鼠口服CIP (200 mg/kg体重/天)1个月,并与格列齐特(5 mg/kg体重/天)进行比较。结果:补充CIP或格列齐特可显著降低血糖水平,增加体重和胰岛素水平。与糖尿病组相比,添加STZ-NAD导致糖尿病大鼠体内酶抗氧化活性降低,而添加CIP显著提高了糖尿病大鼠体内的抗氧化酶水平。结论:CIP具有潜在的抗氧化能力,可能是治疗糖尿病的有效成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Supplementation of Carrot Incorporated Paneer Attenuates Diabetes through its Antioxidant Potential in Streptozotocin-Nicotinamide-Induced Diabetic Rats
Background: The ideal medications for diabetes mellitus (DM) should have less or no adverse effects, thus screening on the antidiabetic activities of plant-based products is in urgent need. Paneer is the fundamental nutritious and complete native dairy products, and natural products incorporated paneer has greatly increased its therapeutic potential.Objective: The current study was undertaken to explore the effects of carrot incorporated paneer (CIP) on blood glucose, body weight, insulin, and enzymatic antioxidants such as superoxide dismutase, catalase, glutathione (GSH) peroxidase, and reduced GSH in streptozotocin (STZ) and nicotinamide (NAD)-induced diabetes in rats.Materials and Methods: Diabetic rats were orally supplemented with CIP (200 mg/kg body weight/day) for 1 month and the effects were compared with gliclazide (5 mg/kg body weight/day).Results: Supplementation of CIP or gliclazide was resulted in noteworthy diminish in the levels of blood glucose and increase in body weight and insulin levels. STZ-NAD administration caused the diminution in enzymatic antioxidant activities in diabetic rats and supplementation with CIP predominantly enhanced the levels of antioxidant enzymes in diabetic rats when contrasted to diabetic group.Conclusion: Hence, the results suggested that CIP has the potential antioxidant capability and may be believed as an efficient curative constituent for the management of DM.
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