谵妄生物标志物研究报告要点(REDEEMS):解释和阐述

Ingrid Amgarth-Duff, Annemarie Hosie, G. Caplan, D. Adamis, L. O. Watne, C. Cunningham, E. Oh, Sophia Wang, H. Lindroth, Robert D. Sanders, B. Olofsson, T. Girard, L. Steiner, S. Vasunilashorn, M. Agar
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引用次数: 1

摘要

尽管对谵妄的潜在生物标志物进行了许多研究,但谵妄的病理生理仍不清楚。证据表明,报告谵妄生物标志物研究的质量是次优的。为了更好地了解谵妄的病理生理,需要更好地报道谵妄的生物标志物研究。为了提高谵妄生物标志物研究报告的稳健性、透明度和统一性,一个国际谵妄研究小组通过三个阶段的过程制定了REDEEMS(谵妄生物标志物研究报告要点)指南,包括系统综述、三轮德尔菲研究和后续共识会议。这一过程产生了9项指导方针,为谵妄液生物标志物研究提供信息。为加强REDEEMS指引的实施,本解释及阐述文件对每一项都作了详细的解释。我们预计REDEEMS指南将通过改进谵妄生物标志物研究的报告,从而提高综合研究结果的能力,从而有助于加速我们对谵妄病理生理学的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reporting Essentials for DElirium bioMarker Studies (REDEEMS): Explanation and Elaboration
Despite many studies of potential delirium biomarkers, delirium pathophysiology remains unclear. Evidence shows that the quality of reporting delirium biomarker studies is sub-optimal. Better reporting of delirium biomarker studies is needed to understand delirium pathophysiology better. To improve robustness, transparency and uniformity of delirium biomarker study reports, the REDEEMS (Reporting Essentials for DElirium bioMarker Studies) guideline was developed by an international group of delirium researchers through a three-stage process, including a systematic review, a three-round Delphi study, and a follow-up consensus meeting. This process resulted in a 9-item guideline to inform delirium fluid biomarker studies. To enhance implementation of the REDEEMS guideline, this Explanation and Elaboration paper provides a detailed explanation of each item. We anticipate that the REDEEMS guideline will help to accelerate our understanding of delirium pathophysiology by improving the reporting of delirium biomarker research and, consequently the capacity to synthesise results across studies.
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