The Possibilities of Working Capacity Maintenance at Organophosphorous Compounds Intoxication

Th e experience of modern local armed confl icts and the monitoring of terrorist activity in the world indicate the possibility of the aff ection of people by organophosphorus compounds (OPs) in combat and as a result of industrial accidents and terrorist acts. It can be predicted that in case of timely use of PPE by the personnel, in addition to lethal and severe aff ections, up to 30 ± 5% of them will be mild forms of intoxication. It is shown in the article, that the actoprotectors with diff erent mechanism of action (hypoxene, octodrine and meldonium) increase the endurance of experimental animals with mild poisoning of OPs in case of single oral administration. Moreover, the degree of inhibition of peripheral blood acetylcholinesterase of all animals treated with model OPs did not diff er between groups and ranged from 8 to 24%. As a result of the experiments on animals, the preparations were distributed in the following order: meldonium