L-glutamic acid effect on changes in biochemical parameters of rats intoxicated by carbon tetrachloride

This study aims to explore the ameliorative effects of L-glutamic acid (L-Glu) against carbon tetrachloride (CCl4) toxicity in male rats. Changes in the activities of alanine and aspartate aminotransferases (ALAT, ASAT) were studied in the tissues and blood of rats. Concentrations of creatinine, triacylglycerol and cholesterol were also determined in the blood of experimental animals. Intraperitoneal administration of CCl4 to rats led to changes in the blood of animals of the studied parameters — an increase of the activities of aminotransferases, triacylglycerol and cholesterol levels. At the same time, a decrease of ALAT activity was observed in the tissues of the myocardium and spleen of intoxicated animals, ASAT in their brain, and in the tissues of the lungs there was an increase in the activity of ALAT and the growth of ASAT in the tissues of the spleen In turn, with additional administration to animals intoxicated with tetrachloromethane L-Glu mitigation or no change in most of the studied indicators was observed, namely, in the blood the activity of ASAT fluctuated within the control values, and the concentrations of triacylglycerol and cholesterol did not change compared to the control. Also under the action of the studied aminoacid, no changes were detected in the activities of ALAT in lung tissue and ASAT in spleen tissue. The obtained results indicate a corrective effect of L-Glu on the physiological and biochemical parameters of rats in their intoxication with carbon tetrachloride.