自组装硅烷和表面的硫醇功能化

M. McGovern, M. Thompson
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引用次数: 10

摘要

用x射线光电子能谱分析评价了硅烷、巯基丙基三甲氧基硅烷和1-(三氟乙酸-)-11-三氯硅十一烷在硅表面反应后的相对厚度和覆盖范围。使用探针n -五氟苯基- n ' -碘乙酰肼,可以估计在空气和无o2条件下反应后底物表面巯基的可用性。虽然三甲氧基硅烷可以产生多层结构,但其附着探针的数量仅为含氟硅烷的3.5倍。这些实验结果证实,1-(三氟乙酸-)-11-三氯硅十一烷是一种更有效的连接剂,用于固定化生物分子到底物表面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Self-assembled silanes and the thiol functionalization of surfaces
The relative thickness and coverage of the silanes, mercaptopropyltrimethoxysilane and 1-(trifluoroacetato-)-11-trichlorosilyl-undecane subsequent to reaction on silicon surfaces has been assessed by X-ray photoelectron spectroscopic analysis. Use of the probe, N-pentafluorophenyl-N′-iodoacetyl hydrazide, allows an estimation of the availability of thiol groups on the substrate surface following reaction in air and in O2-free conditions. Although the trimethoxysilane generates multilayer structures, it is only capable of attaching 3.5 times less probe than the fluorine-containing silane. The results of these experiments confirm that 1-(trifluoroacetato-)-11-trichlorosilyl-undecane is a much more effective linking agent for the immobilization of biomolecules to substrate surfaces.
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