Ebonyi州Abakaliki国家产科瘘中心膀胱阴道瘘患者手术切除膀胱结石的金属和有机特征

U. Okorie, I. Sunday‐Adeoye, J. Obuna, A. Daniyan, K. Ekwedigwe, A. Oje, EN Yakubu, CJ Chukwu, Chukwu Uro, O. Omaka
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The qualitative chemical composition was determined following standard procedures while the structural chemical characterization and functional groups were determined using the Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-Transform Infrared spectroscopy (FTIR). Results: Distilled water and aqueous solvent chloroform extract of W. lateritia demonstrated significant capacity to dissolve bladder stones in-vitro. Chemical compounds identified include uric acid, oxalate, cysteine, and phosphate from the bladder stones. The metals found in the bladder stones were: Ca, Na, Cu, Zn, Mg, B, Pb, and Al. Trace elements can influence the external morphology of growing crystals and may increase or decrease the speed of the crystallization process. 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引用次数: 0

摘要

目的:产科瘘的并发症是膀胱结石的形成,这在阴道膀胱瘘(VVF)患者中很少发生。在本研究中,对尼日利亚埃邦伊州Abakaliki国家产科瘘中心(NOFIC) 2010-2019年间从膀胱阴道瘘患者中取出的膀胱结石的金属和有机特征进行了研究。方法:采用电感耦合等离子体-光学发射光谱法(ICP-OESS)测定膀胱结石在不同溶剂中的溶解度和金属成分。采用气相色谱-质谱联用(GC-MS)和傅里叶变换红外光谱(FTIR)测定结构化学表征和官能团。结果:红土侧枝蒸馏水和氯仿水溶剂萃取物对膀胱结石有明显的体外溶出作用。从膀胱结石中鉴定出的化合物包括尿酸、草酸、半胱氨酸和磷酸盐。在膀胱结石中发现的金属有:Ca, Na, Cu, Zn, Mg, B, Pb和Al。微量元素可以影响生长晶体的外部形态,并可能增加或降低结晶过程的速度。气相色谱-质谱分析发现了以下化合物:甲基2-羟乙基亚砜;二氯甲烷;巯乙胺;1,1 diethoxy dichloroactealdehyde;Cyclopentasiloxane;monoammonium盐;di-Allo-Cystathionine;dichloroacetaldehyde;2 - (2 furyl) 2、5-dimethyltetrahydrofuran;乌洛托品;1、1-Difluoro-1-sila-5-thiacyclooctane;Triacetonetriperoxde;4-氨基水杨酸,3-三甲基硅基(3TMS)衍生物;2, 5-Bis (5-hexyl -(1、3、2)dioxaborinan-2-yloxy)苯。FTIR显示:羟基,羧基,酯,芳香族和脂肪族,证实了所鉴定的化合物。结论:膀胱结石中检出金属(Mg、Ca、Pb等),有机代谢物(草酸盐、胱氨酸、尿酸、磷酸盐、甲基苯丙胺、二氯甲烷、4-氨基水杨酸、3-三甲基硅基等)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metal and organic characterization of bladder stones removed surgically from VesicoVaginal Fistula patients at the National Obstetric Fistula Centre, Abakaliki, Ebonyi State
Objectives: Complication of obstetric fistula is the formation of bladder stones which rarely occur in Vagina-Vesico Fistula (VVF) patients. In this study, the metal and organic characterization of bladder stones removed between 2010-2019 from vesicovaginal fistula patients managed at the National Obstetric Fistula Centre (NOFIC), Abakaliki, Ebonyi State, Nigeria were carried out. Methods: The solubility of the bladder stones in different solvents were investigated and metal compositions were determined using Inductively Coupled Plasma- Optical Emission Spectrometry (ICP-OESS). The qualitative chemical composition was determined following standard procedures while the structural chemical characterization and functional groups were determined using the Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-Transform Infrared spectroscopy (FTIR). Results: Distilled water and aqueous solvent chloroform extract of W. lateritia demonstrated significant capacity to dissolve bladder stones in-vitro. Chemical compounds identified include uric acid, oxalate, cysteine, and phosphate from the bladder stones. The metals found in the bladder stones were: Ca, Na, Cu, Zn, Mg, B, Pb, and Al. Trace elements can influence the external morphology of growing crystals and may increase or decrease the speed of the crystallization process. The GC-MS revealed the presence of the following compounds: methyl 2-Hydroxyethyl sulfoxide; methylene chloride; mercaptamine;1,1diethoxy, dichloroactealdehyde; Cyclopentasiloxane; monoammonium salt; di-Allo-Cystathionine; dichloroacetaldehyde; 2-(2Furyl)-2,5-dimethyltetrahydrofuran; Methenamine; 1,1-Difluoro-1-sila-5-thiacyclooctane; Triacetonetriperoxde; 4-Aminosalicylic acid, 3-Trimethylsilyl (3TMS) derivative;Pentanethiol; and 2,5-Bis-(5-hexyl-[1,3,2]dioxaborinan-2-yloxy)-benzene. FTIR revealed the following: hydroxyl, carboxylic, ester, aromatic, and aliphatic groups, confirming the compounds identified. Conclusion: Metals (Mg, Ca, Pb, etc), organic metabolites (oxalate, cystine, uric acid, phosphate, methenamine, methylene chloride, 4-Aminosalicylic acid, 3-Trimethylsilyl, etc) were found in the bladder stones.
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