{"title":"乙型肝炎病毒la基因型在日本血友病患者中的高流行率","authors":"Takeaki Suou , Toshio Kawatani , Kenichi Nishikawa , Juichi Ueki , Hiroaki Sawada , Shinji Ooi , Minoru Yamada , Hiroyuki Sasaki , Hironaka Kawasaki","doi":"10.1016/0928-4346(96)00260-5","DOIUrl":null,"url":null,"abstract":"<div><p>Japanese hemophiliacs have received a large number of imported coagulation factors from the USA as well as domestic ones. We investigated the prevalence of hepatitis C virus (HCV) genotypes in 25 hemophiliacs and in 461 patients with chronic hepatitis C in the San-in area, west Japan. The prevalence of HCV genotype la was significantly higher in hemophiliacs (36%, <em>P</em> 〈 0.001) than patients with chronic hepatitis C (0.2%). Furthermore, the mixed infection of different genotypes was significantly more frequent in hemophiliacs (20%, <em>P</em> 〈 0.0001) compared to chronic hepatitis C patients (1%). These results suggest that Japanese hemophiliacs could be infected with HCV genotype la by numerous and repeated infusion of imported coagulation factors from the USA.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":"4 6","pages":"Pages 301-304"},"PeriodicalIF":0.0000,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0928-4346(96)00260-5","citationCount":"2","resultStr":"{\"title\":\"High prevalence of hepatitis C virus genotype la in Japanese hemophiliacs\",\"authors\":\"Takeaki Suou , Toshio Kawatani , Kenichi Nishikawa , Juichi Ueki , Hiroaki Sawada , Shinji Ooi , Minoru Yamada , Hiroyuki Sasaki , Hironaka Kawasaki\",\"doi\":\"10.1016/0928-4346(96)00260-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Japanese hemophiliacs have received a large number of imported coagulation factors from the USA as well as domestic ones. We investigated the prevalence of hepatitis C virus (HCV) genotypes in 25 hemophiliacs and in 461 patients with chronic hepatitis C in the San-in area, west Japan. The prevalence of HCV genotype la was significantly higher in hemophiliacs (36%, <em>P</em> 〈 0.001) than patients with chronic hepatitis C (0.2%). Furthermore, the mixed infection of different genotypes was significantly more frequent in hemophiliacs (20%, <em>P</em> 〈 0.0001) compared to chronic hepatitis C patients (1%). These results suggest that Japanese hemophiliacs could be infected with HCV genotype la by numerous and repeated infusion of imported coagulation factors from the USA.</p></div>\",\"PeriodicalId\":13746,\"journal\":{\"name\":\"International Hepatology Communications\",\"volume\":\"4 6\",\"pages\":\"Pages 301-304\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0928-4346(96)00260-5\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Hepatology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0928434696002605\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Hepatology Communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0928434696002605","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
High prevalence of hepatitis C virus genotype la in Japanese hemophiliacs
Japanese hemophiliacs have received a large number of imported coagulation factors from the USA as well as domestic ones. We investigated the prevalence of hepatitis C virus (HCV) genotypes in 25 hemophiliacs and in 461 patients with chronic hepatitis C in the San-in area, west Japan. The prevalence of HCV genotype la was significantly higher in hemophiliacs (36%, P 〈 0.001) than patients with chronic hepatitis C (0.2%). Furthermore, the mixed infection of different genotypes was significantly more frequent in hemophiliacs (20%, P 〈 0.0001) compared to chronic hepatitis C patients (1%). These results suggest that Japanese hemophiliacs could be infected with HCV genotype la by numerous and repeated infusion of imported coagulation factors from the USA.
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