COVID-19患者心电图表现与血清生物标志物的关系

IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Gökhan Perinçek, M. Karakayalı, S. Avci
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The most frequent comorbidities were chronic obstructive pulmonary disease (COPD) and hypertension (HT) in both groups. The incidence of fQRS on the 1st day was significantly higher in patients with negative COVID-19 test (23% for positive RT-PCR versus 35.6% for negative RT-PCR, p = 0.016). QTc values on the 3rd and 5th day were significantly higher in patients with negative RT-PCR (p = 0.045 and p = 0.042, respectively). Albumin and procalcitonin were significantly higher in patients with positive COVID-19 test results (p = 0.018 and p <0.001, respectively). Patients with fragmented QRS presented significantly lower serum albumin (40.62 ± 4.73 g/L vs. 42.92 ± 3.72 g/L, p = 0.01), and protein levels (p = 0.02), as well as lower lymphocyte count, and significantly higher levels of C-reactive protein (47.01 ± 65.01 mg/L vs. 24.55 ± 44.17 mg/L, p = 0.001), D-dimer (p = 0.009), neutrophil count, pro-BNP (p = 0.004), troponin T (p <0.001), NRL and CAR (1.28 ± 1.83 versus 0.6 ± 1.11, p <0.001). Conclusion: Patients with COVID-19 infection presented significantly higher levels of C-reactive protein, D-dimer, neutrophil, pro-BNP, procalcitonin, troponin T, NLR, and CAR, and significantly lower levels of albumin, lymphocyte count, and serum proteins, indicating the level of inflammation and its relationship with myocardial injury. 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引用次数: 0

摘要

背景与目的:本研究的目的是评估COVID-19患者心电图表现与炎症和心肌损伤血液参数的关系。方法:女性159例,男性194例。记录人口统计学、心电图表现(心轴、节律、分支阻滞、ST波和T波改变、室性早搏、早期复极、S1Q3T3、碎片化QRS [fQRS]、率、PR、QRS、QT间期、QTc、p波离散度)、白蛋白、d -二聚体、铁蛋白、原bnp、降钙素、蛋白、肌钙蛋白T、中性粒细胞与淋巴细胞比值(NLR)、c反应蛋白/白蛋白比值(CAR)。结果:本组病例中,女性占45%,男性占55%。患者平均年龄45.7±24.4岁。两组中最常见的合并症是慢性阻塞性肺疾病(COPD)和高血压(HT)。阴性患者第1天fQRS发生率显著高于阴性患者(RT-PCR阳性组23%,阴性组35.6%,p = 0.016)。RT-PCR阴性患者第3、5天的QTc值显著高于对照组(p = 0.045、p = 0.042)。COVID-19检测阳性患者白蛋白和降钙素原显著升高(p = 0.018, p <0.001)。碎片化QRS患者血清白蛋白(40.62±4.73 g/L比42.92±3.72 g/L, p = 0.01)、蛋白水平显著降低(p = 0.02),淋巴细胞计数显著降低,c反应蛋白(47.01±65.01 mg/L比24.55±44.17 mg/L, p = 0.001)、d -二聚体(p = 0.009)、中性粒细胞计数、前bnp (p = 0.004)、肌钙蛋白T (p <0.001)、NRL和CAR(1.28±1.83比0.6±1.11,p <0.001)水平显著升高。结论:COVID-19感染患者c反应蛋白、d -二聚体、中性粒细胞、原bnp、降钙素原、肌钙蛋白T、NLR、CAR水平显著升高,白蛋白、淋巴细胞计数、血清蛋白水平显著降低,提示炎症水平及其与心肌损伤的关系。需要对更大的患者群体进行进一步的随访研究,以开发COVID-19患者的风险预测工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between ECG Findings and Serum Biomarkers in COVID-19 Patients
Abstract Background and aim: The aim of this study was to evaluate the relationship between ECG findings and blood parameters indicative of inflammation and myocardial injury in COVID-19 patients. Methods: The study included 159 females and 194 males. Demographics, ECG findings (axis, rhythm, branch block, ST- and T-wave changes, premature ventricular contractions, early repolarization, S1Q3T3, fragmented QRS [fQRS], rate, PR, QRS, QT interval, QTc, P-wave dispersion) and albumin, D-dimer, ferritin, pro-BNP, procalcitonin, protein, troponin T, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CAR) were recorded. Results: In the study, 45% of the cases were female and 55% were male. The mean age of the included patients was 45.7 ± 24.4 years. The most frequent comorbidities were chronic obstructive pulmonary disease (COPD) and hypertension (HT) in both groups. The incidence of fQRS on the 1st day was significantly higher in patients with negative COVID-19 test (23% for positive RT-PCR versus 35.6% for negative RT-PCR, p = 0.016). QTc values on the 3rd and 5th day were significantly higher in patients with negative RT-PCR (p = 0.045 and p = 0.042, respectively). Albumin and procalcitonin were significantly higher in patients with positive COVID-19 test results (p = 0.018 and p <0.001, respectively). Patients with fragmented QRS presented significantly lower serum albumin (40.62 ± 4.73 g/L vs. 42.92 ± 3.72 g/L, p = 0.01), and protein levels (p = 0.02), as well as lower lymphocyte count, and significantly higher levels of C-reactive protein (47.01 ± 65.01 mg/L vs. 24.55 ± 44.17 mg/L, p = 0.001), D-dimer (p = 0.009), neutrophil count, pro-BNP (p = 0.004), troponin T (p <0.001), NRL and CAR (1.28 ± 1.83 versus 0.6 ± 1.11, p <0.001). Conclusion: Patients with COVID-19 infection presented significantly higher levels of C-reactive protein, D-dimer, neutrophil, pro-BNP, procalcitonin, troponin T, NLR, and CAR, and significantly lower levels of albumin, lymphocyte count, and serum proteins, indicating the level of inflammation and its relationship with myocardial injury. Further follow-up studies are required, on larger patient sets, for the development of risk prediction tools in COVID-19 patients.
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