Drug targeting strategies for liver cancer and other liver diseases

Treatment of liver cancer and other diseases are a challenging task for the current researchers in the pharmaceutical field There are some physiological barriers like RES uptake opsonization and first pass metabolism of therapeutics present that make drug therapy more complex Generally conventional cancer therapy approaches give low response rate or remain un success due to multi drug resistance MDR high clearance rate severe adverse effect due to unwanted drug distribution and in adequate concentration reached in cancer cells Therefore it is a need to develop novel strategies which will target drug molecule specific to affected liver cells In the current era of research and development various approaches have been utilized to improve the drug delivery and drug targeting The new targeting approaches are based on the use of targeting ligands which can conjugate with nanocarrier or with drug molecules These conjugates systems are accumulate passively or actively This review focus on some liver cancer cells specific targeting ligands such as manos phosphate asialoglycoprotein galactoside lactobionic acid PDGF antibodies aptamers avimers which have been utilized to target cancer cell after conjugation with the therapeutic system This review also describes the novel targeting approaches including latest targeting molecules and targeted drug delivery system used for the treatment of liver cancer