{"title":"乙醇金丝桃及其糖苷类黄酮提取物对利血平诱导的瑞士白化小鼠抗抑郁作用的评价","authors":"S. Subakanman, S. Murugan, P. Devi","doi":"10.3923/AJB.2016.1.13","DOIUrl":null,"url":null,"abstract":"The purpose of the study was to investigate the anti-depressant like effect of ethanolic extract of H. hookerianum (EEHh 200 and 400 mg kgG p.o.,) and its glycosidic flavonoid enriched extract of ethanolic extract of H. hookerianum (GFHh 100 mg kgG p.o.,) in reserpine induced (2 mg kgG i.p.,) Swiss albino mice. The flavonoidal constiteuents in EEHh and GFHh was confirmed by HPLC. The behavioral analysis of forced swimming test, tail suspension test, locomotor activity in mice has been conducted. Brain superoxide dismutase, catalase, glutathione and lipid peroxidation were estimated biochemically. Brain monoamine oxidase (A and B) activity has been carried out by double beam spectrophotometer. All the values in this study indicated that the GFHh posses well specified antidepressant activity than EEHh due to higher concentration of flavonoids as confirmed by HPLC.","PeriodicalId":8510,"journal":{"name":"Asian Journal of Biochemistry","volume":"17 1","pages":"1-13"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Evaluation of Antidepressant like Effects of Ethanolic Hypericum hookerianum and its Glycosidic Flavonoid Enriched Extract in Reserpine Induced Swiss Albino Mice\",\"authors\":\"S. Subakanman, S. Murugan, P. Devi\",\"doi\":\"10.3923/AJB.2016.1.13\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The purpose of the study was to investigate the anti-depressant like effect of ethanolic extract of H. hookerianum (EEHh 200 and 400 mg kgG p.o.,) and its glycosidic flavonoid enriched extract of ethanolic extract of H. hookerianum (GFHh 100 mg kgG p.o.,) in reserpine induced (2 mg kgG i.p.,) Swiss albino mice. The flavonoidal constiteuents in EEHh and GFHh was confirmed by HPLC. The behavioral analysis of forced swimming test, tail suspension test, locomotor activity in mice has been conducted. Brain superoxide dismutase, catalase, glutathione and lipid peroxidation were estimated biochemically. Brain monoamine oxidase (A and B) activity has been carried out by double beam spectrophotometer. All the values in this study indicated that the GFHh posses well specified antidepressant activity than EEHh due to higher concentration of flavonoids as confirmed by HPLC.\",\"PeriodicalId\":8510,\"journal\":{\"name\":\"Asian Journal of Biochemistry\",\"volume\":\"17 1\",\"pages\":\"1-13\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3923/AJB.2016.1.13\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3923/AJB.2016.1.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of Antidepressant like Effects of Ethanolic Hypericum hookerianum and its Glycosidic Flavonoid Enriched Extract in Reserpine Induced Swiss Albino Mice
The purpose of the study was to investigate the anti-depressant like effect of ethanolic extract of H. hookerianum (EEHh 200 and 400 mg kgG p.o.,) and its glycosidic flavonoid enriched extract of ethanolic extract of H. hookerianum (GFHh 100 mg kgG p.o.,) in reserpine induced (2 mg kgG i.p.,) Swiss albino mice. The flavonoidal constiteuents in EEHh and GFHh was confirmed by HPLC. The behavioral analysis of forced swimming test, tail suspension test, locomotor activity in mice has been conducted. Brain superoxide dismutase, catalase, glutathione and lipid peroxidation were estimated biochemically. Brain monoamine oxidase (A and B) activity has been carried out by double beam spectrophotometer. All the values in this study indicated that the GFHh posses well specified antidepressant activity than EEHh due to higher concentration of flavonoids as confirmed by HPLC.
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