Early initiation of renal replacement therapy in acute renal injury

Acute kidney injury (AKI) is a widely-seen pathology in the hospital environment. Today, prevention is the best available treatment. Nowadays, one of the most common causes is sepsis-induced AKI, which is seen in critical care patients. Sepsis-induced AKI includes in its pathophysiology injury associated with low kidney perfusion and toxicity caused by inflammatory biomarkers but has a more complex treatment.

There is not yet a consensus of when to initiate renal replacement therapy, but it seems that early initiation confers a better prognosis, as well as that continuous renal therapy, could have an impact on life expectancy and early renal recovery. We analyze epidemiology, pathophysiology, and treatment in the following article, particularly the early initiation of renal replacement therapy in sepsis-induced AKI.