高剂量双重治疗和CYP2C19多态性在幽门螺杆菌根除中的作用

GastroHep Pub Date : 2021-08-06 DOI:10.1002/ygh2.484

Tin Ma Ma Win, M. Htun, Win Phyu Phyu Myint, M. M. Aung, N. Ni

{"title":"高剂量双重治疗和CYP2C19多态性在幽门螺杆菌根除中的作用","authors":"Tin Ma Ma Win, M. Htun, Win Phyu Phyu Myint, M. M. Aung, N. Ni","doi":"10.1002/ygh2.484","DOIUrl":null,"url":null,"abstract":"Helicobacter pylori infect about 50% of the world's population. The efficacy of treatment using standard regimens has declined in recent years, mainly due to widespread development of antibiotic resistance. Use of enhanced acid suppression and antibiotics with lower risk to resistance, will shape the future of treatment for H pylori. High‐dose dual therapy (HDDT) can overcome the effect of CYP2C19 polymorphism thus enhancing acid suppression and may become an option in H pylori eradication.","PeriodicalId":12480,"journal":{"name":"GastroHep","volume":"6 1","pages":"379 - 383"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"High‐dose dual therapy and CYP2C19 polymorphism in Helicobacter pylori eradication\",\"authors\":\"Tin Ma Ma Win, M. Htun, Win Phyu Phyu Myint, M. M. Aung, N. Ni\",\"doi\":\"10.1002/ygh2.484\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Helicobacter pylori infect about 50% of the world's population. The efficacy of treatment using standard regimens has declined in recent years, mainly due to widespread development of antibiotic resistance. Use of enhanced acid suppression and antibiotics with lower risk to resistance, will shape the future of treatment for H pylori. High‐dose dual therapy (HDDT) can overcome the effect of CYP2C19 polymorphism thus enhancing acid suppression and may become an option in H pylori eradication.\",\"PeriodicalId\":12480,\"journal\":{\"name\":\"GastroHep\",\"volume\":\"6 1\",\"pages\":\"379 - 383\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"GastroHep\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/ygh2.484\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"GastroHep","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/ygh2.484","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 2

摘要

幽门螺杆菌感染了世界上大约50%的人口。近年来，使用标准方案的治疗效果有所下降，主要是由于抗生素耐药性的广泛发展。使用增强抑酸和耐药风险较低的抗生素将塑造幽门螺杆菌治疗的未来。高剂量双重治疗(HDDT)可以克服CYP2C19多态性的影响，从而增强酸抑制，可能成为根除幽门螺杆菌的一种选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

High‐dose dual therapy and CYP2C19 polymorphism in Helicobacter pylori eradication

Helicobacter pylori infect about 50% of the world's population. The efficacy of treatment using standard regimens has declined in recent years, mainly due to widespread development of antibiotic resistance. Use of enhanced acid suppression and antibiotics with lower risk to resistance, will shape the future of treatment for H pylori. High‐dose dual therapy (HDDT) can overcome the effect of CYP2C19 polymorphism thus enhancing acid suppression and may become an option in H pylori eradication.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

GastroHep

自引率

0.00%

发文量