纳米乳作为新型给药系统:开发、表征及应用

Nikhil Dhumal, V. Yadav, S. Borkar
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引用次数: 1

摘要

微滴小至亚微米的分散纳米系统称为纳米乳。纳米乳液是一种热力学稳定、透明、各向同性的油、水、表面活性剂和助表面活性剂的液体混合物。纳米乳液的液滴尺寸通常在20到200纳米之间。连续相中分散颗粒的大小和组成是乳状液和纳米乳的主要区别。这种方法旨在缓解传统给药系统所带来的低生物利用度和不合规的问题。今天,纳米乳剂可以用于许多给药途径。纳米乳液配方可以被认为是一种有效的、安全的、符合患者要求的药物递送方法。目前,纳米乳剂在药物治疗、剂型设计和研究方面引起了广泛的关注。表面活性剂和助表面活性剂可以保持纳米乳的稳定成分。本文就纳米乳的种类、制备工艺、稳定性、评价及应用等方面进行了综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanoemulsion as Novel Drug Delivery System: Development, Characterization and Application
A dispersed nano-system with droplet sizes as small as submicrons is called a nanoemulsion. Nanoemulsions are thermodynamically stable, transparent, isotropic liquid mixtures of oil, water, surfactant, and co-surfactant. Nanoemulsion typically has droplet sizes between 20 and 200 nanometer. The size and composition of the scattered particles in a continuous phase are the primary distinctions between an emulsion and a nanoemulsion. This approach is intended to alleviate some of the issues that low bioavailability and noncompliance, two issues with traditional drug delivery systems, bring up.Today, nano emulsion can be created for a number of administration routes. A nano emulsion formulation can be considered an effective, secure, and patient-compliant pharmaceutical delivery method. Nowadays, nano emulsions have attracted a lot of interest in pharmacotherapy, dosage form design, and research. A surfactant and a cosurfactant can preserves the stability components of nanoemulsion. Brief details on the types, preparation process, stability, assessment, and applications of nanoemulsion are provided in this review.  
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