双相情感障碍患者非典型抗精神病药物与肠道微生物群的相互作用

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-03-01 DOI:10.1002/phar.1890

Stephanie A. Flowers, S. Evans, Kristen M. Ward, M. McInnis, V. Ellingrod

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引用次数: 176

摘要

非典型抗精神病药(AAP)类通常与代谢性疾病相关，但这种风险的机制基础尚不清楚。由于有报道将肠道细菌功能与代谢性疾病联系起来，我们假设成人AAP治疗会导致肠道生态失调，从而增强代谢标准。本报告描述了最近的研究结果，将AAP治疗与双相情感障碍(BD)人类队列中肠道微生物群的差异联系起来。

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Interaction Between Atypical Antipsychotics and the Gut Microbiome in a Bipolar Disease Cohort

The atypical antipsychotic (AAP) class is often associated with metabolic disease, but the mechanistic underpinnings of this risk are not understood. Due to reports linking gut bacteria function to metabolic disease, we hypothesize that AAP treatment in adults results in gut dysbiosis potentiating metabolic criteria. This report describes recent findings linking AAP treatment with differences in gut microbiota communities in a human cohort with bipolar disorder (BD).

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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

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