{"title":"新型n3 -取代3,4 -二氢嘧啶-2(1H)- 1衍生物的简便合成","authors":"R. Shastri","doi":"10.7598/cst2018.1543","DOIUrl":null,"url":null,"abstract":"A simple and convenient method for the synthesis of N3-substituted 3,4-dihydropyrimidinones has been achieved by the condensation of 3,4-dihydropyrimidinones with benzoyl chloride in pyridine. The advantages of this method are excellent yields, short reaction time, no-side reaction, operational simplicity and ease in experimental procedure. The key intermediate 3,4dihydropyrimidin-2(1H)-ones have been synthesized by condensation of β-ketoester, aromatic aldehydes and N-methyl urea using PTSA.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":"16 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Convenient Synthesis of Some Novel N3-Substituted 3, 4-Dihydropyrimidin-2(1H)-one Derivatives\",\"authors\":\"R. Shastri\",\"doi\":\"10.7598/cst2018.1543\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A simple and convenient method for the synthesis of N3-substituted 3,4-dihydropyrimidinones has been achieved by the condensation of 3,4-dihydropyrimidinones with benzoyl chloride in pyridine. The advantages of this method are excellent yields, short reaction time, no-side reaction, operational simplicity and ease in experimental procedure. The key intermediate 3,4dihydropyrimidin-2(1H)-ones have been synthesized by condensation of β-ketoester, aromatic aldehydes and N-methyl urea using PTSA.\",\"PeriodicalId\":10087,\"journal\":{\"name\":\"Chemical science transactions\",\"volume\":\"16 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical science transactions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7598/cst2018.1543\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical science transactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7598/cst2018.1543","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Convenient Synthesis of Some Novel N3-Substituted 3, 4-Dihydropyrimidin-2(1H)-one Derivatives
A simple and convenient method for the synthesis of N3-substituted 3,4-dihydropyrimidinones has been achieved by the condensation of 3,4-dihydropyrimidinones with benzoyl chloride in pyridine. The advantages of this method are excellent yields, short reaction time, no-side reaction, operational simplicity and ease in experimental procedure. The key intermediate 3,4dihydropyrimidin-2(1H)-ones have been synthesized by condensation of β-ketoester, aromatic aldehydes and N-methyl urea using PTSA.
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