P.M. Honoré , J. Jamez , M. Wauthier , B. Pirenne , J.P. Pelgrim , T. Dugernier
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Dugernier","doi":"10.1016/S1164-6756(00)80008-0","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>—</span><span><p>Introduction</p></span></li><li><span>—</span><span><p>Enjeux</p><ul><li><span>•</span><span><p>Cibles: cascade inflammatoire</p></span></li><li><span>•</span><span><p>Cibles: voies de la dépression myocardique</p></span></li><li><span>•</span><span><p>Le concept de clairance effective</p></span></li><li><span>•</span><span><p>Modèles animaux expérimentaux</p></span></li><li><span>•</span><span><p>Études humaines rétrospectives et prospectives</p></span></li></ul></span></li></ul><p></p><ul><li><span>—</span><span><p>Relation entre les effets cliniques et l’extraction de médiateurs</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Optimalisation de l’hémofiltration pour favoriser l’extraction desmédiateurs</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Mise en œuvre, indications actuelles et risques potentiels</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Raisons d’être des futures études</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Conclusions</p></span></li></ul></div><div><p></p><ul><li><span>—</span><span><p>Introduction</p></span></li><li><span>—</span><span><p>Potential issues</p><ul><li><span>•</span><span><p>Targeting the inflammatory cascade:</p><ul><li><span>-</span><span><p>removal by filtration</p></span></li><li><span>-</span><span><p>removal by adsorption</p></span></li></ul></span></li><li><span>•</span><span><p>Targeting the myocardial depressant pathway:</p><ul><li><span>-</span><span><p>removal by filtration</p></span></li><li><span>-</span><span><p>removal by adsorption</p></span></li></ul></span></li></ul></span></li></ul><p></p><ul><li><span>—</span><span><p>The concept of additional clearance</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Animal experimental models</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Human retrospective and prospective studies</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Importance of the timing of the procedure</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Optimization of hemofiltration for enhancing mediator removal</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Implementation, current indications and potential harmful effects</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Rationale for future trials</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Conclusions</p></span></li></ul></div>","PeriodicalId":101063,"journal":{"name":"Réanimation Urgences","volume":"9 4","pages":"Pages 289-297"},"PeriodicalIF":0.0000,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1164-6756(00)80008-0","citationCount":"7","resultStr":"{\"title\":\"Removal of mediators by hemofiltration in septic shock: where do we stand?\",\"authors\":\"P.M. Honoré , J. Jamez , M. Wauthier , B. Pirenne , J.P. Pelgrim , T. Dugernier\",\"doi\":\"10.1016/S1164-6756(00)80008-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>—</span><span><p>Introduction</p></span></li><li><span>—</span><span><p>Enjeux</p><ul><li><span>•</span><span><p>Cibles: cascade inflammatoire</p></span></li><li><span>•</span><span><p>Cibles: voies de la dépression myocardique</p></span></li><li><span>•</span><span><p>Le concept de clairance effective</p></span></li><li><span>•</span><span><p>Modèles animaux expérimentaux</p></span></li><li><span>•</span><span><p>Études humaines rétrospectives et prospectives</p></span></li></ul></span></li></ul><p></p><ul><li><span>—</span><span><p>Relation entre les effets cliniques et l’extraction de médiateurs</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Optimalisation de l’hémofiltration pour favoriser l’extraction desmédiateurs</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Mise en œuvre, indications actuelles et risques potentiels</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Raisons d’être des futures études</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Conclusions</p></span></li></ul></div><div><p></p><ul><li><span>—</span><span><p>Introduction</p></span></li><li><span>—</span><span><p>Potential issues</p><ul><li><span>•</span><span><p>Targeting the inflammatory cascade:</p><ul><li><span>-</span><span><p>removal by filtration</p></span></li><li><span>-</span><span><p>removal by adsorption</p></span></li></ul></span></li><li><span>•</span><span><p>Targeting the myocardial depressant pathway:</p><ul><li><span>-</span><span><p>removal by filtration</p></span></li><li><span>-</span><span><p>removal by adsorption</p></span></li></ul></span></li></ul></span></li></ul><p></p><ul><li><span>—</span><span><p>The concept of additional clearance</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Animal experimental models</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Human retrospective and prospective studies</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Importance of the timing of the procedure</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Optimization of hemofiltration for enhancing mediator removal</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Implementation, current indications and potential harmful effects</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Rationale for future trials</p></span></li></ul><p></p><ul><li><span>—</span><span><p>Conclusions</p></span></li></ul></div>\",\"PeriodicalId\":101063,\"journal\":{\"name\":\"Réanimation Urgences\",\"volume\":\"9 4\",\"pages\":\"Pages 289-297\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1164-6756(00)80008-0\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Réanimation Urgences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1164675600800080\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Réanimation Urgences","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1164675600800080","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
摘要
•目标:炎症级联•目标:心肌抑制途径•有效清除的概念•实验动物模型•回顾性和前瞻性人类研究-临床效果与介质提取之间的关系-优化血滤以促进介质提取-实施，指导当前和未来的潜在风险存在的理由—研究———介绍潜在结论(美国•调查the inflammatory瀑布:-removal by filtration-removal by the myocardial吸附美国•调查depressant路径:-removal by filtration-removal by吸附—附加清除—动物实验模型的概念》—Human回顾与前瞻研究—圣母圣母—优化程序的时机非常of hemofiltration for提升mediator消除-实施、当前适应症和潜在有害影响-未来试验的理由-结论
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