前列腺癌细胞中Ca2+信号的调控

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Channels Pub Date : 2016-01-08 DOI:10.1080/19336950.2015.1137176

Tatiana Kilch, S. Kappel, C. Peinelt

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引用次数: 11

摘要

精确的细胞内Ca2+信号是保证细胞正常功能的关键。随后，Ca2+信号的不平衡，特别是在储存操作的Ca2+进入(SOCE)中，导致免疫疾病和癌症中的几种病理生理功能障碍。我们最近报道了前列腺癌细胞中异聚的Orai1/Orai3 SOCE通道和瞬时受体电位褪黑素-4 (TRPM4)通道。我们在此总结了我们的发现，并提供了Ca2+信号在前列腺癌细胞中的调节模型。

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Regulation of Ca2+ signaling in prostate cancer cells

AbstractPrecise intracellular Ca2+ signaling is crucial to ensure proper cellular functions. Subsequently, imbalances in Ca2+ signaling, particularly in store-operated Ca2+ entry (SOCE), contribute to several pathophysiological malfunctions in immune diseases and cancer. We lately reported on heteromeric Orai1/Orai3 SOCE channels and transient receptor potential melastatin-4 (TRPM4) channels in prostate cancer cells. We here sum up our findings and provide a model for the regulation of Ca2+ signaling in prostate cancer cells.

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来源期刊

Channels 生物-生化与分子生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Channels is an open access journal for all aspects of ion channel research. The journal publishes high quality papers that shed new light on ion channel and ion transporter/exchanger function, structure, biophysics, pharmacology, and regulation in health and disease. Channels welcomes interdisciplinary approaches that address ion channel physiology in areas such as neuroscience, cardiovascular sciences, cancer research, endocrinology, and gastroenterology. Our aim is to foster communication among the ion channel and transporter communities and facilitate the advancement of the field.