异烟肼诱发的系统性红斑狼疮:病例报告

Jitendra H Vaghela, Yogesh Solanki, Krishna Lakhani, Bhargav Purohit
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引用次数: 0

摘要

系统性红斑狼疮(SLE)可由多种药物诱发,如肼屈嗪、普鲁卡因胺、异烟肼、甲基多巴、氯丙嗪、奎尼丁和米诺环素。一名患者入院时主诉发热、寒战和全身僵硬。在确诊为结核性脑膜炎后,患者接受了抗结核治疗。由于患者病情未见好转,医生对其进行了详细检查,发现抗核抗体水平升高。会诊医生诊断患者患有系统性红斑狼疮。由于异烟肼会增加患系统性红斑狼疮的风险,因此被怀疑是罪魁祸首。从抗结核治疗方案中撤除异烟肼后,患者病情好转并出院。根据 WHO-UMC 和 Naranjo 的因果关系评估标准,该反应很可能与异烟肼有关。根据修改后的哈特维格和西格尔量表,该反应为中度严重(4b 级)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isoniazid-Induced Systemic Lupus Erythematosus: A Case Report.

Systemic lupus erythematosus (SLE) can be induced by various medications, such as hydralazine, procainamide, isoniazid, methyldopa, chlorpromazine, quinidine, and minocycline. A patient was admitted complaining of fever with chills and rigor. After being diagnosed with tuberculous meningitis, the patient was given antituberculosis treatment. As the patient did not improve, detailed investigations were conducted, and elevated antinuclear antibody levels were found. The consulting physician diagnosed that the patient was suffering from SLE. As isoniazid is associated with an increased risk of developing SLE, it was suspected as the culprit drug. After withdrawing isoniazid from the antituberculosis treatment regimen, the patient improved and was discharged. Based on the WHO-UMC and Naranjo's causality assessment criteria, an association between the reaction and isoniazid was deemed probable. The reaction was moderately severe (level 4b) according to the modified Hartwig and Siegel scale.

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