2-乙酰吡啶- n(4)-甲基-3-硫代氨基脲(L)及其金属配合物的合成与晶体结构:抗癌活性[Cu(L)(OAc)]

IF 0.4 4区化学 Q4 Chemistry

Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry Pub Date : 2021-07-01 DOI:10.56042/ijca.v60i4.43196

Chinmoy Biswasa, A. Chatterjeea, Sreelekshmi Sreekumarb, M. KiranB., R. Ghosha

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引用次数: 0

摘要

报道了N(4)-取代2-乙酰吡啶-N(4)-甲基-3-硫代氨基脲(L)及其金属配合物[Cu(L)(OAc)](1)和[ZnL(OAc)]2(2)的合成和结构表征。在这两个复合物中，发现1对人肺癌细胞系(A549)具有良好的抗癌活性。荧光显微镜观察到在用1处理癌细胞时形成的活性氧。该复合物的IC50值为0.72M，低于顺铂对A549的IC50值。

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Synthesis and crystal structures of 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its metal complexes: Anticancer activity of [Cu(L)(OAc)]

Synthesis and structural characterization of N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its two metal complexes [Cu(L)(OAc)] (1) and [ZnL(OAc)]2 (2) are reported. Between the two complexes 1 is found to have good anticancer activity against Human lung cancer cell line (A549). Fluorescence microscopy finds the formation of reactive oxygen species on treatment of the cancer cells with 1. The IC50 value of the complex is measured as 0.72 M which is lower than that of cisplatin against A549.

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来源期刊

Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry 化学-化学综合

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0.00%

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审稿时长

6-12 weeks

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