R. Bassey, O. Yama, A. Osinubi, C. C. Noronha, A. Okanlawon
{"title":"塔希提诺丽膳食补充剂对咖啡因处理的Sprague- Dawley大鼠心脏的微观解剖影响","authors":"R. Bassey, O. Yama, A. Osinubi, C. C. Noronha, A. Okanlawon","doi":"10.5580/95d","DOIUrl":null,"url":null,"abstract":"AIM: This study was designed to assess the effects of Tahitian Noni on the heart of Caffeine-treated rats.METHODS: Thirty adult Sprague-Dawley rats, weighing between 105-200 g were used. They were divided into 6 groups of 5 rats each. Group 1 was the control. Group 2 received 200mg/kg of caffeine for 8 weeks, group 3 received 200mg/kg of caffeine for 4 weeks and 5ml/kg of Noni for another 4 weeks, group 4 received both 200mg/kg of caffeine and 5ml/kg of Noni for 8 weeks, group 5 received 5ml/kg of Noni for 8 weeks, group 6 received 5ml/kg of Noni for 4 weeks and 200mg/kg of caffeine for another 4 weeks. RESULTS: There was no significant difference in cholesterol levels and body weights of treated groups when compared to control. The histological sections showed focal necrosis in groups 2, 3and 4 with degenerative changes observed in group 2. Groups 5 and 6 tended towards normal.CONCLUSION: Tahitian noni dietary supplement modulates the effect of a high dose of caffeine on the heart.","PeriodicalId":89628,"journal":{"name":"The Internet journal of mental health","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Micro-Anatomical Effect Of Tahitian Noni Dietary Supplement On The Heart Of Caffeine-Treated Sprague- Dawley Rats\",\"authors\":\"R. Bassey, O. Yama, A. Osinubi, C. C. Noronha, A. Okanlawon\",\"doi\":\"10.5580/95d\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"AIM: This study was designed to assess the effects of Tahitian Noni on the heart of Caffeine-treated rats.METHODS: Thirty adult Sprague-Dawley rats, weighing between 105-200 g were used. They were divided into 6 groups of 5 rats each. Group 1 was the control. Group 2 received 200mg/kg of caffeine for 8 weeks, group 3 received 200mg/kg of caffeine for 4 weeks and 5ml/kg of Noni for another 4 weeks, group 4 received both 200mg/kg of caffeine and 5ml/kg of Noni for 8 weeks, group 5 received 5ml/kg of Noni for 8 weeks, group 6 received 5ml/kg of Noni for 4 weeks and 200mg/kg of caffeine for another 4 weeks. RESULTS: There was no significant difference in cholesterol levels and body weights of treated groups when compared to control. The histological sections showed focal necrosis in groups 2, 3and 4 with degenerative changes observed in group 2. Groups 5 and 6 tended towards normal.CONCLUSION: Tahitian noni dietary supplement modulates the effect of a high dose of caffeine on the heart.\",\"PeriodicalId\":89628,\"journal\":{\"name\":\"The Internet journal of mental health\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet journal of mental health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/95d\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet journal of mental health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/95d","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Micro-Anatomical Effect Of Tahitian Noni Dietary Supplement On The Heart Of Caffeine-Treated Sprague- Dawley Rats
AIM: This study was designed to assess the effects of Tahitian Noni on the heart of Caffeine-treated rats.METHODS: Thirty adult Sprague-Dawley rats, weighing between 105-200 g were used. They were divided into 6 groups of 5 rats each. Group 1 was the control. Group 2 received 200mg/kg of caffeine for 8 weeks, group 3 received 200mg/kg of caffeine for 4 weeks and 5ml/kg of Noni for another 4 weeks, group 4 received both 200mg/kg of caffeine and 5ml/kg of Noni for 8 weeks, group 5 received 5ml/kg of Noni for 8 weeks, group 6 received 5ml/kg of Noni for 4 weeks and 200mg/kg of caffeine for another 4 weeks. RESULTS: There was no significant difference in cholesterol levels and body weights of treated groups when compared to control. The histological sections showed focal necrosis in groups 2, 3and 4 with degenerative changes observed in group 2. Groups 5 and 6 tended towards normal.CONCLUSION: Tahitian noni dietary supplement modulates the effect of a high dose of caffeine on the heart.
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