社会应激的表观遗传效应与表观遗传

Halime Sena Ekmekci̇, Sümeyye Muftarevi̇ç
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引用次数: 0

摘要

造成压力的社会事件会导致生物的表观遗传变化。研究个体所经历的社会事件对基因组上的表观遗传标记的影响,创造了社会表观遗传学领域。社会表观遗传学研究诸如贫困、战争创伤和童年虐待等社会心理压力因素对表观遗传机制的影响。表观遗传机制在不改变DNA序列的情况下改变基因组结构中的化学标记。在这些机制中,DNA甲基化尤其可能对可能发生在社会心理环境中的压力源产生不同的表型效应。创伤后应激障碍是创伤事件改变表观遗传表达对表型影响的最重要证据之一。表观遗传领域已经表明,在某些情况下,由环境影响引发的表观遗传变化可以代代相传。这个领域提供了对许多心理障碍的基础的更好的理解。本文综述了社会表观遗传学、创伤后应激障碍和表观遗传学的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetic Effects of Social Stress and Epigenetic Inheritance
Social events that cause stress can cause epigenetic changes on living things. The study of the effects of social events experienced by an individual on epigenetic marks on the genome has created the field of social epigenetics. Social epigenetics examines the effects of psychosocial stress factors such as poverty, war trauma and childhood abuse on epigenetic mechanisms. Epigenetic mechanisms alter chemical markers in the genome structure without changing the DNA sequence. Among these mechanisms, DNA methylation in particular may have different phenotypic effects in response to stressors that may occur in the psychosocial environment. Post-traumatic stress disorder is one of the most significant proofs of the effects of epigenetic expressions altered due to traumatic events on the phenotype. The field of epigenetic inheritance has shown that epigenetic changes triggered by environmental influences can, in some cases, be transmitted through generations. This field provides a better understanding of the basis of many psychological disorders. This review provides an overview of social epigenetics, PTSD, and epigenetic inheritance.
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来源期刊
自引率
0.00%
发文量
43
审稿时长
8 weeks
期刊介绍: Psikiyatride Güncel Yaklaşımlar / Current Approaches in Psychiatry is an online peer reviewed bilingual journal aiming to publish updated current review articles on all aspects of psychiatry and related sciences (i.e behavioral sciences, psychology, psychopharmacology, neuropsychiatry, neurosciences, psychiatric nursing) in Turkish or English. The journal accepts articles on not only current subjects but also on classical subjects to become an educational source for all psychiatric residents, specialists and related professionals. The journal accepts articles on not only current subjects but also on classical subjects to become an educational source for all psychiatric residents, specialists and related professionals. Journal also publishes a special issue which includes only research papers in every volume.
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