G. Graf , M. Jelen , D. Jamnig , H. Schabus , W. Pipam , R. Likar
{"title":"甲氧胺酸和萘普生在成人选择性扁桃体切除术后的疗效和副反应率的比较:一项随机双盲研究","authors":"G. Graf , M. Jelen , D. Jamnig , H. Schabus , W. Pipam , R. Likar","doi":"10.1016/j.acpain.2008.07.003","DOIUrl":null,"url":null,"abstract":"<div><p><span>The aim of this study was to assess the efficacy and side-effects of mefenamic acid as compared to </span>naproxen<span> administered postoperatively to patients following elective tonsillectomy.</span></p></div><div><h3>Methods</h3><p>Fifty patients received either naproxen or mefenamic acid given postoperatively in a randomized fashion following elective tonsillectomy. General anaesthesia<span><span> for the tonsillectomies was administered in a standardized fashion. Pain intensity was assessed postoperatively at rest and on exertion using the numeric rating scale (NRS) and </span>analgesic consumption. The side-effects were also documented.</span></p></div><div><h3>Results</h3><p>Forty-one patients were included in the assessment. There were no significant differences with respect to the demographic data. After the 48th postoperative hour the NRS score demonstrated a significant difference in pain intensity at rest and on exertion in favour of the mefenamic acid group. There was no difference in the rate of side-effects between the two groups.</p></div><div><h3>Conclusion</h3><p>Mefenamic acid is a more effective analgesic than naproxen given postoperatively following elective tonsillectomies.</p></div>","PeriodicalId":100023,"journal":{"name":"Acute Pain","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.acpain.2008.07.003","citationCount":"7","resultStr":"{\"title\":\"A comparison of the efficacy and rate of side-effects of mefenamic acid and naproxen in adult patients following elective tonsillectomy: A randomized double-blind study\",\"authors\":\"G. Graf , M. Jelen , D. Jamnig , H. Schabus , W. Pipam , R. Likar\",\"doi\":\"10.1016/j.acpain.2008.07.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>The aim of this study was to assess the efficacy and side-effects of mefenamic acid as compared to </span>naproxen<span> administered postoperatively to patients following elective tonsillectomy.</span></p></div><div><h3>Methods</h3><p>Fifty patients received either naproxen or mefenamic acid given postoperatively in a randomized fashion following elective tonsillectomy. General anaesthesia<span><span> for the tonsillectomies was administered in a standardized fashion. Pain intensity was assessed postoperatively at rest and on exertion using the numeric rating scale (NRS) and </span>analgesic consumption. The side-effects were also documented.</span></p></div><div><h3>Results</h3><p>Forty-one patients were included in the assessment. There were no significant differences with respect to the demographic data. After the 48th postoperative hour the NRS score demonstrated a significant difference in pain intensity at rest and on exertion in favour of the mefenamic acid group. There was no difference in the rate of side-effects between the two groups.</p></div><div><h3>Conclusion</h3><p>Mefenamic acid is a more effective analgesic than naproxen given postoperatively following elective tonsillectomies.</p></div>\",\"PeriodicalId\":100023,\"journal\":{\"name\":\"Acute Pain\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.acpain.2008.07.003\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acute Pain\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1366007108001484\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acute Pain","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1366007108001484","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A comparison of the efficacy and rate of side-effects of mefenamic acid and naproxen in adult patients following elective tonsillectomy: A randomized double-blind study
The aim of this study was to assess the efficacy and side-effects of mefenamic acid as compared to naproxen administered postoperatively to patients following elective tonsillectomy.
Methods
Fifty patients received either naproxen or mefenamic acid given postoperatively in a randomized fashion following elective tonsillectomy. General anaesthesia for the tonsillectomies was administered in a standardized fashion. Pain intensity was assessed postoperatively at rest and on exertion using the numeric rating scale (NRS) and analgesic consumption. The side-effects were also documented.
Results
Forty-one patients were included in the assessment. There were no significant differences with respect to the demographic data. After the 48th postoperative hour the NRS score demonstrated a significant difference in pain intensity at rest and on exertion in favour of the mefenamic acid group. There was no difference in the rate of side-effects between the two groups.
Conclusion
Mefenamic acid is a more effective analgesic than naproxen given postoperatively following elective tonsillectomies.
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