A. Heimberger, L. Kong, Mohamed K. Abou-Ghazal, Chantal Reina-Ortiz, David S. Yang, Jun Wei, W. Qiao, R. Schmittling, G. Archer, J. Sampson, N. Hiraoka, W. Priebe, G. Fuller, R. Sawaya
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The role of tregs in human glioma patients and their inhibition with a novel STAT-3 inhibitor.
Several recent clinical trials for high-grade gliomas have demonstrated promising results. Nonetheless, despite improvement in survival, these patients ultimately die of tumor progression. Malignant glioma patients are profoundly immunosuppressed, and a fundamental understanding of which types of glioma have immune resistance mediated by Tregs is required for developing and initiating specific immunotherapeutic approaches that may target these cells.
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