泛免疫炎症值和全身免疫炎症指数:它们是结节病的有用指标吗?

Adem Ertürk, A. Balcı
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引用次数: 0

摘要

背景/目的:结节病是一种以多脏器浸润为特征的多系统炎性疾病。由于缺乏被广泛接受的生物标志物,研究人员已经探索了结节病的替代和以前未探索的参数。本研究旨在探讨包括全身免疫炎症指数(SII)和泛免疫炎症值(PIV)在内的各种标志物在结节病患者中的应用。方法:于2019年1月至2023年2月进行病例对照研究。该研究包括75名结节病患者和93名年龄、性别和体重指数相匹配的健康人。记录结节病的相关特征,如肺分期和肺外受累。研究人员调查了SII、PIV、降钙素原、红细胞沉降率(ESR)、c反应蛋白(CRP)等生化指标,以及全血细胞计数(包括中性粒细胞、淋巴细胞、单核细胞、血小板计数、血红蛋白、平均血小板体积[MPV]、红细胞分布宽度[RDW])。结果:病例组与对照组年龄、性别分布相似(P=0.258、P=0.196)。患者组淋巴细胞绝对计数明显低于对照组(P=0.035)。患者的RDW (P=0.007)、血小板/淋巴细胞比(P=0.028)和ESR (P<0.001)值均显著高于对照组。在PIV和SII等其他变量方面,两组间无显著差异。PIV与肺分期、结节性红斑的存在呈显著的弱正相关。结论:结节病患者PIV和SII值与对照组相似。PIV与肺分期以及MPV与结节性红斑之间的正相关表明与结节病相关特征的潜在关系,并证明了这些易于获得且价格低廉的标志物在患者管理中的价值。需要全面的研究来阐明SII和/或PIV是否可以用于评估结节病患者的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pan-immune-inflammation value and systemic immune-inflammation index: Are they useful markers in sarcoidosis?
Background/Aim: Sarcoidosis is a multisystem inflammatory disease characterized by the infiltration of various organs. Due to the lack of a widely-accepted biomarker, researchers have explored alternative and previously unexplored parameters in sarcoidosis. This study aimed to investigate the utility of various markers, including the systemic immune-inflammation index (SII) and pan-immune-inflammation value (PIV), in patients with sarcoidosis. Methods: A case-control study was conducted between January 2019 and February 2023. The study included 75 patients diagnosed with sarcoidosis, and 93 healthy individuals matched for age, sex, and body mass index. Sarcoidosis-related features, such as lung stage and extrapulmonary involvement, were recorded. The researchers investigated SII, PIV, procalcitonin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), other biochemical results, and complete blood counts (including neutrophil, lymphocyte, monocyte, platelet counts, hemoglobin, mean platelet volume [MPV], and red cell distribution width [RDW]). Results: The age and sex distribution were similar in both the case and control groups (P=0.258 and P=0.196, respectively). The patient group had a significantly lower absolute lymphocyte count than the control group (P=0.035). Patients’ RDW (P=0.007), platelet-to-lymphocyte ratio (P=0.028), and ESR (P<0.001) values were significantly higher compared to controls. No significant difference was observed between the two groups regarding other variables, including PIV and SII. There was a significant weak positive correlation between PIV and lung stage, as well as between MPV and the presence of erythema nodosum. Conclusion: PIV and SII values in patients with sarcoidosis were similar to controls. The positive correlations between PIV and lung stage and between MPV and erythema nodosum suggest potential relationships with sarcoidosis-related features and demonstrate the value of these readily available and inexpensive markers in patient management. Comprehensive studies are needed to clarify whether SII and/or PIV can be used to assess the characteristics of patients with sarcoidosis.
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