IBS phenotype associated with obesity and overweight: treatment tactics for patient-centered management

One of the most urgent problems of modern healthcare in Russia and worldwide is the increase in the number of people with overweight and obesity. It is generally recognized that overweight and obesity increase the risk of coronary heart disease, hypertension, type 2 diabetes mellitus, cholelithiasis, non-alcoholic fatty liver disease (NAFLD). At the same time, recent data indicate that pathomorphism of other chronic non-infectious diseases was also noted during preserving trend towards an increase in the obesity prevalence, for which the presence of overweight or obesity was not considered a traditional risk factor. Using the example of a clinical case concerning a female patient with a combined course of irritable bowel syndrome (IBS) and NAFLD, the article presents up-to-date information on risk factors and pathogenetic mechanisms of such comorbidity and suggests treatment methods to improve the therapy efficacy for this patient cohort. The presence of common risk factors and pathogenetic mechanisms creates the basis for the formation of comorbidity of IBS and NAFLD, which requires the development of patient-centered management. KEYWORDS: irritable bowel syndrome, non-alcoholic fatty liver disease, metabolic syndrome, intestinal permeability, intestinal microbiota, mebeverin, ademetionine. FOR CITATION: Livzan M.A., Gaus O.V., Fedorin M.M. IBS phenotype associated with obesity and overweight: treatment tactics for patient- centered management. Russian Medical Inquiry. 2023;7(5):323–331 (in Russ.). DOI: 10.32364/2587-6821-2023-7-5-11.