更陡的动作电位持续时间恢复斜率增加心室颤动的风险:一项模拟研究

Yi Zheng, D. Wei, Zuxiang Fang
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引用次数: 1

摘要

动作电位持续时间恢复(APDR)被认为与心脏电生理的稳定性有关。采用基于临床结果考虑分段线性动作电位持续时间恢复的Wei-Harumi模型模拟心室颤动(VF)。我们在模拟中发现,APDR斜率更陡的心脏模型需要更少的异位刺激来触发VF。提示APDR可能影响心脏对VF的易感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Steeper Action Potential Duration Restitution Slope Increases Risk of Ventricular Fibrillation: A Simulation Study
Action potential duration restitution (APDR) is thought to be relevant to the stability of cardiac electrophysiology. Ventricular fibrillation (VF) was simulated using the Wei-Harumi model by taking into account piecewise linear action potential duration restitution based on clinical findings. We found, in the simulation, that heart model with steeper slope of APDR required less ectopic stimuli to trigger VF. This result suggested that the APDR may affect cardiac vulnerability to VF.
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