Flow system for calibration and interference examination in two-component analysis

The next flow system with fully rotary valve (FRV) has been designed and applied for calibration purposes in chemical analysis. In the present case the system was aimed at performing two-component analysis, namely, at preparing the set of two-component standard solutions and using them for calibration and determination of both components in a sample. It has been proven that the FRV, if suitably configured and operated, was capable of using only two initial standards for preparation of eight two-component solutions and furthermore, of composing them in accordance with the incomplete 3² experimental plan. Owing to that, the mathematical models then formulated on the basis of measurement data could serve not only for estimation of the concentrations of both analytes in a sample, but also for evaluation and elimination of the mutual influences between them. It has been experimentally revealed that the system developed allows the calibration procedure to be performed with low consumption of time, work, and reagents, providing reliable analytical results and valuable information about interferences. © 2000 John Wiley & Sons, Inc. Lab Robotics and Automation 12:228–235, 2000