肺动脉高压患者日常体力活动的相关因素

Layse N G Lima, F. Mendes, M. M. Moreira, D. Oliveira, M. C. Pereira
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引用次数: 2

摘要

背景:肺动脉高压(PAH)降低了日常身体活动(DLPA),但其潜在机制尚不完全清楚。本研究的目的是评估PAH患者的DLPA,并确定其与功能能力和心理因素的关系。方法:这是一项在巴西大学医院进行的DLPA单中心前瞻性研究。20例稳定型PAH患者平均年龄44.3±13.2岁,80%特发性PAH和20%与胶原蛋白疾病相关的PAH,功能分类(CF-NYHA I/II/III: N=7/10/3),通过加速度计完成7天的每日步行步数监测,并进行肺功能测试、6分钟步行测试(6MWT)、1分钟坐站立测试(STST)和超声心动图。同时填写3份问卷(生活质量[SF-36]、医院焦虑抑郁量表[HADS]、曼彻斯特日常生活呼吸活动量表[MRADL])。结果:平均日步数为4280±2351步,平均活动时间为41.6±19.3分钟。结论:PAH患者DLPA降低,与日常生活活动限制、功能能力和抑郁症状有关,但与回声变量无关。这些发现强化了运动限制在PAH中的多因素性质。此外,他们认为,对习惯性活动的客观测量可能为PAH评估提供附加价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors associated with daily physical activity in patients with Pulmonary arterial hypertension
Background: Pulmonary arterial hypertension (PAH) reduces daily physical activity (DLPA) but the underlying mechanisms are not fully understood. The aim of this study was to evaluate DLPA and to determine its relationship to functional capacity and psychological factors in patients with PAH. Methods: This was a single-center prospective study of DLPA conducted in a Brazilian University hospital. Twenty stable PAH subjects mean age 44.3 ± 13.2 yrs, 80% Idiopathic PAH and 20% PAH associated to collagen disease, functional class (CF-NYHA I/II/III: N=7/10/3) completed a 7-day monitoring of daily walking steps by accelerometer and performed pulmonary function tests, 6-minute walk test (6MWT), 1-min sit-to-stand test (STST), and echocardiogram. They also answered 3 questionnaires (quality of life [SF-36], hospital anxiety and depression scale [HADS], and Manchester Respiratory Activities of Daily Living [MRADL]). Results: The mean number of daily steps was 4,280 ± 2,351, and the mean activity time was 41.6 ± 19.3minutes. The mean number of daily steps correlated positively (p Conclusion: DLPA is reduced in PAH and is associated to limitation of daily living activities, functional capacity and depression symptoms, but not with echo variables. These findings reinforce the multifactorial nature of exercise limitation in PAH. Also, they suggest that objective measurement of habitual activity might provide additive value in PAH assessment.
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